Nonlinkage of major histocompatibility complex class I and class II loci in bony fishes

Akie Sato, Felipe Figueroa, Brent W. Murray, Edward Málaga-Trillo, Zofia Zaleska-Rutczynska, Holger Sültmann, Satoru Toyosawa, Claus Wedekind, Nicole Steck, Jan Klein

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

In tetrapods, the functional (classical) class I and class II B loci of the major histocompatibility complex (Mhc) are tightly linked in a single chromosomal region. In an earlier study, we demonstrated that in the zebrafish, Danio rerio, order Cypriniformes, the two classes are present on different chromosomes. Here, we show that the situation is similar in the stickleback, Gasterosteus aculeatus, order Gasterosteiformes, the common guppy, Poecilia reticulata, order Cyprinodontiformes, and the cichlid fish Oreochromis niloticus, order Perciformes. These data, together with unpublished results from other laboratories suggest that in all Euteleostei, the classical class I and class II B loci are in separate linkage groups, and that in at least some of these taxa, the class II loci are in two different groups. Since Euteleostei are at least as numerous as tetrapods, in approximately one-half of jawed vertebrates, the class I and class II regions are not linked.

Original languageEnglish (US)
Pages (from-to)108-116
Number of pages9
JournalImmunogenetics
Volume51
Issue number2
DOIs
StatePublished - Jan 1 2000

Fingerprint

Poecilia
Smegmamorpha
Cichlids
Zebrafish
Major Histocompatibility Complex
Fishes
Cyprinodontiformes
Cypriniformes
Perciformes
Vertebrates
Chromosomes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

Cite this

Sato, A., Figueroa, F., Murray, B. W., Málaga-Trillo, E., Zaleska-Rutczynska, Z., Sültmann, H., ... Klein, J. (2000). Nonlinkage of major histocompatibility complex class I and class II loci in bony fishes. Immunogenetics, 51(2), 108-116. https://doi.org/10.1007/s002510050019
Sato, Akie ; Figueroa, Felipe ; Murray, Brent W. ; Málaga-Trillo, Edward ; Zaleska-Rutczynska, Zofia ; Sültmann, Holger ; Toyosawa, Satoru ; Wedekind, Claus ; Steck, Nicole ; Klein, Jan. / Nonlinkage of major histocompatibility complex class I and class II loci in bony fishes. In: Immunogenetics. 2000 ; Vol. 51, No. 2. pp. 108-116.
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Sato, A, Figueroa, F, Murray, BW, Málaga-Trillo, E, Zaleska-Rutczynska, Z, Sültmann, H, Toyosawa, S, Wedekind, C, Steck, N & Klein, J 2000, 'Nonlinkage of major histocompatibility complex class I and class II loci in bony fishes', Immunogenetics, vol. 51, no. 2, pp. 108-116. https://doi.org/10.1007/s002510050019

Nonlinkage of major histocompatibility complex class I and class II loci in bony fishes. / Sato, Akie; Figueroa, Felipe; Murray, Brent W.; Málaga-Trillo, Edward; Zaleska-Rutczynska, Zofia; Sültmann, Holger; Toyosawa, Satoru; Wedekind, Claus; Steck, Nicole; Klein, Jan.

In: Immunogenetics, Vol. 51, No. 2, 01.01.2000, p. 108-116.

Research output: Contribution to journalArticle

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Sato A, Figueroa F, Murray BW, Málaga-Trillo E, Zaleska-Rutczynska Z, Sültmann H et al. Nonlinkage of major histocompatibility complex class I and class II loci in bony fishes. Immunogenetics. 2000 Jan 1;51(2):108-116. https://doi.org/10.1007/s002510050019