Nonsteroidal antiinflammatory drugs and leukotriene receptor antagonists

James H. Lewis, Jonathan G. Stine

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Nonsteroidal antiinflammatory drugs (NSAIDs) are among the most commonly implicated agents for nonacetaminophen-related hepatotoxicity. Disease-modifying antirheumatic drugs and leukotriene receptor antagonists are less likely to cause drug-induced liver injury (DILI). With the appearance of several large international DILI registries, the incidence of NSAID-related liver injury can be more precisely determined. This chapter presents an update on the clinical presentation and pathological spectrum of hepatotoxicity with these classes of agents, including reports of patients who progressed to acute liver failure. Diclofenac and sulindac remain the most commonly reported NSAIDs associated with acute DILI in the United States, while nimesulide, a COX-2 inhibitor still available in some countries, holds the distinction of having caused the most acute liver failure.

Original languageEnglish (US)
Title of host publicationDrug-Induced Liver Disease
PublisherElsevier Inc.
Pages369-401
Number of pages33
ISBN (Print)9780123878175
DOIs
StatePublished - Aug 27 2013

Fingerprint

Leukotriene Antagonists
Drug Receptors
Chemical and Drug Induced Liver Injury
Anti-Inflammatory Agents
Acute Liver Failure
nimesulide
Pharmaceutical Preparations
Sulindac
Antirheumatic Agents
Diclofenac
Cyclooxygenase 2 Inhibitors
Registries
Liver
Incidence
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Lewis, James H. ; Stine, Jonathan G. / Nonsteroidal antiinflammatory drugs and leukotriene receptor antagonists. Drug-Induced Liver Disease. Elsevier Inc., 2013. pp. 369-401
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Nonsteroidal antiinflammatory drugs and leukotriene receptor antagonists. / Lewis, James H.; Stine, Jonathan G.

Drug-Induced Liver Disease. Elsevier Inc., 2013. p. 369-401.

Research output: Chapter in Book/Report/Conference proceedingChapter

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