North American Contact Dermatitis Group patch test results for 2007-2008

Anthony F. Fransway, Kathryn A. Zug, Donald V. Belsito, Vincent A. DeLeo, Joseph F. Fowler, Howard I. Maibach, James Marks, C. G Toby Mathias, Melanie D. Pratt, Robert L. Rietschel, Denis Sasseville, Frances J. Storrs, James S. Taylor, Erin M. Warshaw, Joel Dekoven, Matthew Zirwas

Research output: Contribution to journalArticle

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Abstract

Background: The North American Contact Dermatitis Group (NACDG) tests patients with suspected allergic contact dermatitis to a broad series of screening allergens and publishes periodic reports. Objective: The aims of this study were to report the NACDG patch-testing results from January 1, 2007, to December 31, 2008, and to compare results to pooled test data from the previous 2 and 10 years to analyze trends in allergen sensitivity. Methods and Materials: Standardized patch testing with 65 allergens was used at 13 centers in North America. χ2 analysis was used for comparisons. Results: A total of 5085 patients were tested; 11.8% (598) had an occupationally related skin condition, and 65.3% (3319) had at least 1 allergic patch test reaction, which is identical to the NACDG data from 2005 to 2006. The top 15 most frequently positive allergens were nickel sulfate (19.5%), Myroxylon pereirae (11.0%), neomycin (10.1%), fragrance mix I (9.4%), quaternium-15 (8.6%), cobalt chloride (8.4%), bacitracin (7.9%), formaldehyde (7.7%), methyldibromoglutaronitrile/ phenoxyethanol (5.5%), p-phenylenediamine (5.3%), propolis (4.9%), carba mix (4.5%), potassium dichromate (4.1%), fragrance mix II (3.6%), and methylchloroisothiazolinone/methylisothiazolinone (3.6%). There were significant increases in positivity rates to nickel, methylchloroisothiazolinone/ methylisothiazolinone, and benzophenone-3. During the same period of study, there were significant decreases in positivity rates to neomycin, fragrance mix I, formaldehyde, thiuram mix, cinnamic aldehyde, propylene glycol, epoxy resin, diazolidinyl urea, amidoamine, ethylenediamine, benzocaine, p-tert-butylphenol formaldehyde resin, dimethylol dimethyl hydantoin, cocamidopropyl betaine, glutaraldehyde, mercaptobenzothiazole, tosylamide formaldehyde resin, budesonide, disperse blue 106, mercapto mix, and chloroxylenol. Twenty-four percent (1221) had a relevant positive reaction to a non-NACDG supplementary allergen; and 180 of these reactions were occupationally relevant. Conclusions: Periodic analysis, surveillance, and publication of multicenter study data sets document trends in allergen reactivity incidence assessed in the patch test clinic setting and provide information on new allergens of relevance.

Original languageEnglish (US)
Pages (from-to)10-21
Number of pages12
JournalDermatitis
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Patch Tests
Contact Dermatitis
Allergens
Formaldehyde
ethylenediamine
Neomycin
Myroxylon
Thiram
Benzocaine
Potassium Dichromate
Hydantoins
Propolis
Epoxy Resins
Bacitracin
Budesonide
Propylene Glycol
Allergic Contact Dermatitis
Glutaral
North America
Nickel

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Immunology and Allergy

Cite this

Fransway, A. F., Zug, K. A., Belsito, D. V., DeLeo, V. A., Fowler, J. F., Maibach, H. I., ... Zirwas, M. (2013). North American Contact Dermatitis Group patch test results for 2007-2008. Dermatitis, 24(1), 10-21. https://doi.org/10.1097/DER.0b013e318277ca50
Fransway, Anthony F. ; Zug, Kathryn A. ; Belsito, Donald V. ; DeLeo, Vincent A. ; Fowler, Joseph F. ; Maibach, Howard I. ; Marks, James ; Mathias, C. G Toby ; Pratt, Melanie D. ; Rietschel, Robert L. ; Sasseville, Denis ; Storrs, Frances J. ; Taylor, James S. ; Warshaw, Erin M. ; Dekoven, Joel ; Zirwas, Matthew. / North American Contact Dermatitis Group patch test results for 2007-2008. In: Dermatitis. 2013 ; Vol. 24, No. 1. pp. 10-21.
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abstract = "Background: The North American Contact Dermatitis Group (NACDG) tests patients with suspected allergic contact dermatitis to a broad series of screening allergens and publishes periodic reports. Objective: The aims of this study were to report the NACDG patch-testing results from January 1, 2007, to December 31, 2008, and to compare results to pooled test data from the previous 2 and 10 years to analyze trends in allergen sensitivity. Methods and Materials: Standardized patch testing with 65 allergens was used at 13 centers in North America. χ2 analysis was used for comparisons. Results: A total of 5085 patients were tested; 11.8{\%} (598) had an occupationally related skin condition, and 65.3{\%} (3319) had at least 1 allergic patch test reaction, which is identical to the NACDG data from 2005 to 2006. The top 15 most frequently positive allergens were nickel sulfate (19.5{\%}), Myroxylon pereirae (11.0{\%}), neomycin (10.1{\%}), fragrance mix I (9.4{\%}), quaternium-15 (8.6{\%}), cobalt chloride (8.4{\%}), bacitracin (7.9{\%}), formaldehyde (7.7{\%}), methyldibromoglutaronitrile/ phenoxyethanol (5.5{\%}), p-phenylenediamine (5.3{\%}), propolis (4.9{\%}), carba mix (4.5{\%}), potassium dichromate (4.1{\%}), fragrance mix II (3.6{\%}), and methylchloroisothiazolinone/methylisothiazolinone (3.6{\%}). There were significant increases in positivity rates to nickel, methylchloroisothiazolinone/ methylisothiazolinone, and benzophenone-3. During the same period of study, there were significant decreases in positivity rates to neomycin, fragrance mix I, formaldehyde, thiuram mix, cinnamic aldehyde, propylene glycol, epoxy resin, diazolidinyl urea, amidoamine, ethylenediamine, benzocaine, p-tert-butylphenol formaldehyde resin, dimethylol dimethyl hydantoin, cocamidopropyl betaine, glutaraldehyde, mercaptobenzothiazole, tosylamide formaldehyde resin, budesonide, disperse blue 106, mercapto mix, and chloroxylenol. Twenty-four percent (1221) had a relevant positive reaction to a non-NACDG supplementary allergen; and 180 of these reactions were occupationally relevant. Conclusions: Periodic analysis, surveillance, and publication of multicenter study data sets document trends in allergen reactivity incidence assessed in the patch test clinic setting and provide information on new allergens of relevance.",
author = "Fransway, {Anthony F.} and Zug, {Kathryn A.} and Belsito, {Donald V.} and DeLeo, {Vincent A.} and Fowler, {Joseph F.} and Maibach, {Howard I.} and James Marks and Mathias, {C. G Toby} and Pratt, {Melanie D.} and Rietschel, {Robert L.} and Denis Sasseville and Storrs, {Frances J.} and Taylor, {James S.} and Warshaw, {Erin M.} and Joel Dekoven and Matthew Zirwas",
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Fransway, AF, Zug, KA, Belsito, DV, DeLeo, VA, Fowler, JF, Maibach, HI, Marks, J, Mathias, CGT, Pratt, MD, Rietschel, RL, Sasseville, D, Storrs, FJ, Taylor, JS, Warshaw, EM, Dekoven, J & Zirwas, M 2013, 'North American Contact Dermatitis Group patch test results for 2007-2008', Dermatitis, vol. 24, no. 1, pp. 10-21. https://doi.org/10.1097/DER.0b013e318277ca50

North American Contact Dermatitis Group patch test results for 2007-2008. / Fransway, Anthony F.; Zug, Kathryn A.; Belsito, Donald V.; DeLeo, Vincent A.; Fowler, Joseph F.; Maibach, Howard I.; Marks, James; Mathias, C. G Toby; Pratt, Melanie D.; Rietschel, Robert L.; Sasseville, Denis; Storrs, Frances J.; Taylor, James S.; Warshaw, Erin M.; Dekoven, Joel; Zirwas, Matthew.

In: Dermatitis, Vol. 24, No. 1, 01.01.2013, p. 10-21.

Research output: Contribution to journalArticle

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T1 - North American Contact Dermatitis Group patch test results for 2007-2008

AU - Fransway, Anthony F.

AU - Zug, Kathryn A.

AU - Belsito, Donald V.

AU - DeLeo, Vincent A.

AU - Fowler, Joseph F.

AU - Maibach, Howard I.

AU - Marks, James

AU - Mathias, C. G Toby

AU - Pratt, Melanie D.

AU - Rietschel, Robert L.

AU - Sasseville, Denis

AU - Storrs, Frances J.

AU - Taylor, James S.

AU - Warshaw, Erin M.

AU - Dekoven, Joel

AU - Zirwas, Matthew

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: The North American Contact Dermatitis Group (NACDG) tests patients with suspected allergic contact dermatitis to a broad series of screening allergens and publishes periodic reports. Objective: The aims of this study were to report the NACDG patch-testing results from January 1, 2007, to December 31, 2008, and to compare results to pooled test data from the previous 2 and 10 years to analyze trends in allergen sensitivity. Methods and Materials: Standardized patch testing with 65 allergens was used at 13 centers in North America. χ2 analysis was used for comparisons. Results: A total of 5085 patients were tested; 11.8% (598) had an occupationally related skin condition, and 65.3% (3319) had at least 1 allergic patch test reaction, which is identical to the NACDG data from 2005 to 2006. The top 15 most frequently positive allergens were nickel sulfate (19.5%), Myroxylon pereirae (11.0%), neomycin (10.1%), fragrance mix I (9.4%), quaternium-15 (8.6%), cobalt chloride (8.4%), bacitracin (7.9%), formaldehyde (7.7%), methyldibromoglutaronitrile/ phenoxyethanol (5.5%), p-phenylenediamine (5.3%), propolis (4.9%), carba mix (4.5%), potassium dichromate (4.1%), fragrance mix II (3.6%), and methylchloroisothiazolinone/methylisothiazolinone (3.6%). There were significant increases in positivity rates to nickel, methylchloroisothiazolinone/ methylisothiazolinone, and benzophenone-3. During the same period of study, there were significant decreases in positivity rates to neomycin, fragrance mix I, formaldehyde, thiuram mix, cinnamic aldehyde, propylene glycol, epoxy resin, diazolidinyl urea, amidoamine, ethylenediamine, benzocaine, p-tert-butylphenol formaldehyde resin, dimethylol dimethyl hydantoin, cocamidopropyl betaine, glutaraldehyde, mercaptobenzothiazole, tosylamide formaldehyde resin, budesonide, disperse blue 106, mercapto mix, and chloroxylenol. Twenty-four percent (1221) had a relevant positive reaction to a non-NACDG supplementary allergen; and 180 of these reactions were occupationally relevant. Conclusions: Periodic analysis, surveillance, and publication of multicenter study data sets document trends in allergen reactivity incidence assessed in the patch test clinic setting and provide information on new allergens of relevance.

AB - Background: The North American Contact Dermatitis Group (NACDG) tests patients with suspected allergic contact dermatitis to a broad series of screening allergens and publishes periodic reports. Objective: The aims of this study were to report the NACDG patch-testing results from January 1, 2007, to December 31, 2008, and to compare results to pooled test data from the previous 2 and 10 years to analyze trends in allergen sensitivity. Methods and Materials: Standardized patch testing with 65 allergens was used at 13 centers in North America. χ2 analysis was used for comparisons. Results: A total of 5085 patients were tested; 11.8% (598) had an occupationally related skin condition, and 65.3% (3319) had at least 1 allergic patch test reaction, which is identical to the NACDG data from 2005 to 2006. The top 15 most frequently positive allergens were nickel sulfate (19.5%), Myroxylon pereirae (11.0%), neomycin (10.1%), fragrance mix I (9.4%), quaternium-15 (8.6%), cobalt chloride (8.4%), bacitracin (7.9%), formaldehyde (7.7%), methyldibromoglutaronitrile/ phenoxyethanol (5.5%), p-phenylenediamine (5.3%), propolis (4.9%), carba mix (4.5%), potassium dichromate (4.1%), fragrance mix II (3.6%), and methylchloroisothiazolinone/methylisothiazolinone (3.6%). There were significant increases in positivity rates to nickel, methylchloroisothiazolinone/ methylisothiazolinone, and benzophenone-3. During the same period of study, there were significant decreases in positivity rates to neomycin, fragrance mix I, formaldehyde, thiuram mix, cinnamic aldehyde, propylene glycol, epoxy resin, diazolidinyl urea, amidoamine, ethylenediamine, benzocaine, p-tert-butylphenol formaldehyde resin, dimethylol dimethyl hydantoin, cocamidopropyl betaine, glutaraldehyde, mercaptobenzothiazole, tosylamide formaldehyde resin, budesonide, disperse blue 106, mercapto mix, and chloroxylenol. Twenty-four percent (1221) had a relevant positive reaction to a non-NACDG supplementary allergen; and 180 of these reactions were occupationally relevant. Conclusions: Periodic analysis, surveillance, and publication of multicenter study data sets document trends in allergen reactivity incidence assessed in the patch test clinic setting and provide information on new allergens of relevance.

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Fransway AF, Zug KA, Belsito DV, DeLeo VA, Fowler JF, Maibach HI et al. North American Contact Dermatitis Group patch test results for 2007-2008. Dermatitis. 2013 Jan 1;24(1):10-21. https://doi.org/10.1097/DER.0b013e318277ca50