Novel Citric Acid-Based Biodegradable Elastomers for Tissue Engineering

Jian Yang, Antonio R. Webb, Guillermo A. Ameer

Research output: Contribution to journalArticle

368 Citations (Scopus)

Abstract

The synthesis and characterization of a novel biodegradable elastomer, poly(1,8-octanediol-co-citric acid) (POC), for use in tissue engineering were described. Citric acid was chosen as a polyfunctional monomer because it is a non-toxic metabolic product of the body. Tubular and sponge-like POC scaffolds with inter-connected pore structures were fabricated using molds and salt leaching technique. The results suggest that POC tube scaffolds are strong enough to act as a temporary template for blood vessels engineered in vivo.

Original languageEnglish (US)
Pages (from-to)511-516
Number of pages6
JournalAdvanced Materials
Volume16
Issue number6
DOIs
StatePublished - Mar 18 2004

Fingerprint

Elastomers
Citric acid
Tissue engineering
Scaffolds
Citric Acid
Blood vessels
Molds
Pore structure
Leaching
Salts
Monomers

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Yang, Jian ; Webb, Antonio R. ; Ameer, Guillermo A. / Novel Citric Acid-Based Biodegradable Elastomers for Tissue Engineering. In: Advanced Materials. 2004 ; Vol. 16, No. 6. pp. 511-516.
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Novel Citric Acid-Based Biodegradable Elastomers for Tissue Engineering. / Yang, Jian; Webb, Antonio R.; Ameer, Guillermo A.

In: Advanced Materials, Vol. 16, No. 6, 18.03.2004, p. 511-516.

Research output: Contribution to journalArticle

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