Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia

Zheng Ge, Min Li, Gang Zhao, Lichan Xiao, Yan Gu, Xilian Zhou, Michael D. Yu, Jianyong Li, Sinisa Dovat, Chunhua Song

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Genetic mutations on signaling pathways are found in patients with T-cell acute lymphoblastic leukemia (T-ALL) and act as markers of high-risk leukemia. Mutations in dynamin 2 (DNM2) have been reported in T-ALL, particularly in early T-cell precursor-ALL. In the present study, DNM2 mutations were screened by sequencing DNM2 exons obtained by polymerase chain reaction amplification and gel purification in adult T-ALL patients. A total of 4 novel DNM2 mutations were identified in adult T-ALL patients, with a mutation rate of 9.5%, and the DNM2 mutations were found to co-exist with NOTCH1 and PHD finger protein 6, and were also associated with high-risk leukemia. A high rate of silent mutation was also found in the patients, but no significant association was found between the silent mutations and patients’ clinical features. The present findings suggested the DNM2 mutations may be involved in the oncogenesis of T-ALL.

Original languageEnglish (US)
Pages (from-to)2746-2751
Number of pages6
JournalOncology Letters
Volume12
Issue number4
DOIs
StatePublished - Oct 2016

Fingerprint

Dynamin II
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Mutation
Leukemia
T-Lymphoid Precursor Cells
Mutation Rate
Fingers
Exons
Carcinogenesis
Gels
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ge, Zheng ; Li, Min ; Zhao, Gang ; Xiao, Lichan ; Gu, Yan ; Zhou, Xilian ; Yu, Michael D. ; Li, Jianyong ; Dovat, Sinisa ; Song, Chunhua. / Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia. In: Oncology Letters. 2016 ; Vol. 12, No. 4. pp. 2746-2751.
@article{2a6f9e7de654404898e0fd187fc7aaba,
title = "Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia",
abstract = "Genetic mutations on signaling pathways are found in patients with T-cell acute lymphoblastic leukemia (T-ALL) and act as markers of high-risk leukemia. Mutations in dynamin 2 (DNM2) have been reported in T-ALL, particularly in early T-cell precursor-ALL. In the present study, DNM2 mutations were screened by sequencing DNM2 exons obtained by polymerase chain reaction amplification and gel purification in adult T-ALL patients. A total of 4 novel DNM2 mutations were identified in adult T-ALL patients, with a mutation rate of 9.5{\%}, and the DNM2 mutations were found to co-exist with NOTCH1 and PHD finger protein 6, and were also associated with high-risk leukemia. A high rate of silent mutation was also found in the patients, but no significant association was found between the silent mutations and patients’ clinical features. The present findings suggested the DNM2 mutations may be involved in the oncogenesis of T-ALL.",
author = "Zheng Ge and Min Li and Gang Zhao and Lichan Xiao and Yan Gu and Xilian Zhou and Yu, {Michael D.} and Jianyong Li and Sinisa Dovat and Chunhua Song",
year = "2016",
month = "10",
doi = "10.3892/ol.2016.4993",
language = "English (US)",
volume = "12",
pages = "2746--2751",
journal = "Oncology Letters",
issn = "1792-1074",
publisher = "Spandidos Publications",
number = "4",

}

Ge, Z, Li, M, Zhao, G, Xiao, L, Gu, Y, Zhou, X, Yu, MD, Li, J, Dovat, S & Song, C 2016, 'Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia', Oncology Letters, vol. 12, no. 4, pp. 2746-2751. https://doi.org/10.3892/ol.2016.4993

Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia. / Ge, Zheng; Li, Min; Zhao, Gang; Xiao, Lichan; Gu, Yan; Zhou, Xilian; Yu, Michael D.; Li, Jianyong; Dovat, Sinisa; Song, Chunhua.

In: Oncology Letters, Vol. 12, No. 4, 10.2016, p. 2746-2751.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia

AU - Ge, Zheng

AU - Li, Min

AU - Zhao, Gang

AU - Xiao, Lichan

AU - Gu, Yan

AU - Zhou, Xilian

AU - Yu, Michael D.

AU - Li, Jianyong

AU - Dovat, Sinisa

AU - Song, Chunhua

PY - 2016/10

Y1 - 2016/10

N2 - Genetic mutations on signaling pathways are found in patients with T-cell acute lymphoblastic leukemia (T-ALL) and act as markers of high-risk leukemia. Mutations in dynamin 2 (DNM2) have been reported in T-ALL, particularly in early T-cell precursor-ALL. In the present study, DNM2 mutations were screened by sequencing DNM2 exons obtained by polymerase chain reaction amplification and gel purification in adult T-ALL patients. A total of 4 novel DNM2 mutations were identified in adult T-ALL patients, with a mutation rate of 9.5%, and the DNM2 mutations were found to co-exist with NOTCH1 and PHD finger protein 6, and were also associated with high-risk leukemia. A high rate of silent mutation was also found in the patients, but no significant association was found between the silent mutations and patients’ clinical features. The present findings suggested the DNM2 mutations may be involved in the oncogenesis of T-ALL.

AB - Genetic mutations on signaling pathways are found in patients with T-cell acute lymphoblastic leukemia (T-ALL) and act as markers of high-risk leukemia. Mutations in dynamin 2 (DNM2) have been reported in T-ALL, particularly in early T-cell precursor-ALL. In the present study, DNM2 mutations were screened by sequencing DNM2 exons obtained by polymerase chain reaction amplification and gel purification in adult T-ALL patients. A total of 4 novel DNM2 mutations were identified in adult T-ALL patients, with a mutation rate of 9.5%, and the DNM2 mutations were found to co-exist with NOTCH1 and PHD finger protein 6, and were also associated with high-risk leukemia. A high rate of silent mutation was also found in the patients, but no significant association was found between the silent mutations and patients’ clinical features. The present findings suggested the DNM2 mutations may be involved in the oncogenesis of T-ALL.

UR - http://www.scopus.com/inward/record.url?scp=84983408394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983408394&partnerID=8YFLogxK

U2 - 10.3892/ol.2016.4993

DO - 10.3892/ol.2016.4993

M3 - Article

AN - SCOPUS:84983408394

VL - 12

SP - 2746

EP - 2751

JO - Oncology Letters

JF - Oncology Letters

SN - 1792-1074

IS - 4

ER -