Novel polymorphism in the a4 region of the amyloid precursor protein gene in a patient without alzheimer's disease

Michael L. Peacock, James Warren, Jr., Allen D. Roses, John K. Fink

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We found a novel polymorphism in the amyloid precursor protein (APP) gene in a patient with ischemic cerebrovascular disease who had no evidence of Alzheimer's disease (AD). This polymorphism deletes a fok I restriction enzyme site and causes the substitution of threonine for alanine at codon 673. This is adjacent to the site at which APP is thought to undergo cleavage in AD. Analysis of this polymorphism may provide insight into the basis of APP processing.

Original languageEnglish (US)
Pages (from-to)1254-1256
Number of pages3
JournalNeurology
Volume43
Issue number6
StatePublished - Jan 1 1993

Fingerprint

Amyloid beta-Protein Precursor
Alzheimer Disease
Genes
Cerebrovascular Disorders
Threonine
Codon
Alanine
Enzymes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Peacock, Michael L. ; Warren, Jr., James ; Roses, Allen D. ; Fink, John K. / Novel polymorphism in the a4 region of the amyloid precursor protein gene in a patient without alzheimer's disease. In: Neurology. 1993 ; Vol. 43, No. 6. pp. 1254-1256.
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Novel polymorphism in the a4 region of the amyloid precursor protein gene in a patient without alzheimer's disease. / Peacock, Michael L.; Warren, Jr., James; Roses, Allen D.; Fink, John K.

In: Neurology, Vol. 43, No. 6, 01.01.1993, p. 1254-1256.

Research output: Contribution to journalArticle

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