Novel polyphosphazene/poly(lactide-co-glycolide) blends: Miscibility and degradation studies

Sobrasua E.M. Ibim, Archel M.A. Ambrosio, Michael S. Kwon, Saadiq F. El-Amin, Harry R. Allcock, Cato T. Laurencin

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

A novel biodegradable polymer blend was developed for potential biomedical applications. A 50:50 poly(lactide-co-glycolide) (PLAGA) was blended in a 50:50 ratio with the followiing polyphosphazenes (PPHOS):poly[(25% ethyl glycinato)(75% p-methylphenoxy)phosphazene[, poly[(50% ethyl glycinato)(50% p-methylphenoxy)phosphazene], and poly[(75% ethyl glycinato)(25% p-methylphenoxy)phosphazene] to obtain Blends A, B, and C, respectively, using a mutual solvent technique. The miscibility of these blends was determined by measuring their glass transition temperature (T(g)) using differential scanning calorimetry. After fabrication using a casting technique, the degradation of the matrices was examined. Differential scanning calorimetry showed one glass transition temperature for each blend which was between the T(g)'s of their respective parent polymers indicating miscibility of the blends. Surface analysis by scanning electron microscopy showed the matrices to have smooth uniform surfaces. Degradation studies showed near-zero order degradation kinetics for the blends with Blends A and B losing 10% of their mass after two weeks and Blend C degrading more rapidly (30% mass loss during the same period) .These findings suggest that these novel biodegradable PLAGA/PPHOS blends may be useful for biomedical purposes.

Original languageEnglish (US)
Pages (from-to)1565-1569
Number of pages5
JournalBiomaterials
Volume18
Issue number23
DOIs
StatePublished - Jan 1 1997

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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    Ibim, S. E. M., Ambrosio, A. M. A., Kwon, M. S., El-Amin, S. F., Allcock, H. R., & Laurencin, C. T. (1997). Novel polyphosphazene/poly(lactide-co-glycolide) blends: Miscibility and degradation studies. Biomaterials, 18(23), 1565-1569. https://doi.org/10.1016/S0142-9612(97)80009-9