Novel Pulsatile Diagonal Pump for Pediatric Extracorporeal Life Support System

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A novel pulsatile rotary flow pump has been used in clinical extracorporeal life support (ECLS) in Europe. The objective of this study is to evaluate the Medos Deltastream DP3 diagonal pump (Medos Medizintechnik AG, Stolberg, Germany) in a simulated pediatric ECLS system. The ECLS circuit consisted of a Medos Hilite 800LT hollow fiber membrane oxygenator (Medos Medizintechnik AG), a Medos Deltastream DP3 diagonal pump, a 10Fr Terumo TenderFlow Pediatric Arterial Cannula (Terumo Corporation, Tokyo, Japan), and an arterial/venous tubing. All trials were conducted at flow rates ranging from 200-800mL/min (in 200mL/min increments) under a blood temperature of 35°C using human blood (hematocrit 40%). The postcannula pressure was maintained 60mmHg by a Hoffman clamp. Real-time pressure and flow data were recorded using a Labview-based acquisition system (National Instruments, Austin, TX, USA). The results showed that the Medos Deltastream DP3 can generate effective pulsatile flow without backflow, provide higher flow rates and pressures than nonpulsatile flow, and then create surplus hemodynamic energy and more total hemodynamic energy than nonpulsatile flow. Pulsatility increased with increased speed differential values and flow rates, while the oxygenator pressure drop increased at an acceptable level. The Medos Deltastream DP3 diagonal pump can provide adequate quality of pulsatility without backflow, and generate more hemodynamic energy under pulsatile mode in a simulated pediatric ECLS system.

Original languageEnglish (US)
Pages (from-to)37-47
Number of pages11
JournalArtificial organs
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Life Support Systems
Extracorporeal Membrane Oxygenation
Pediatrics
Hemodynamics
Oxygenators
Pumps
Pulsatile Flow
Flow rate
Pressure
Blood
Membrane Oxygenators
Rotational flow
Pulsatile flow
Tokyo
Clamping devices
Tubing
Hematocrit
Pressure drop
Germany
Japan

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

Cite this

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abstract = "A novel pulsatile rotary flow pump has been used in clinical extracorporeal life support (ECLS) in Europe. The objective of this study is to evaluate the Medos Deltastream DP3 diagonal pump (Medos Medizintechnik AG, Stolberg, Germany) in a simulated pediatric ECLS system. The ECLS circuit consisted of a Medos Hilite 800LT hollow fiber membrane oxygenator (Medos Medizintechnik AG), a Medos Deltastream DP3 diagonal pump, a 10Fr Terumo TenderFlow Pediatric Arterial Cannula (Terumo Corporation, Tokyo, Japan), and an arterial/venous tubing. All trials were conducted at flow rates ranging from 200-800mL/min (in 200mL/min increments) under a blood temperature of 35°C using human blood (hematocrit 40{\%}). The postcannula pressure was maintained 60mmHg by a Hoffman clamp. Real-time pressure and flow data were recorded using a Labview-based acquisition system (National Instruments, Austin, TX, USA). The results showed that the Medos Deltastream DP3 can generate effective pulsatile flow without backflow, provide higher flow rates and pressures than nonpulsatile flow, and then create surplus hemodynamic energy and more total hemodynamic energy than nonpulsatile flow. Pulsatility increased with increased speed differential values and flow rates, while the oxygenator pressure drop increased at an acceptable level. The Medos Deltastream DP3 diagonal pump can provide adequate quality of pulsatility without backflow, and generate more hemodynamic energy under pulsatile mode in a simulated pediatric ECLS system.",
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Novel Pulsatile Diagonal Pump for Pediatric Extracorporeal Life Support System. / Wang, Shigang; Kunselman, Allen R.; Ündar, Akif.

In: Artificial organs, Vol. 37, No. 1, 01.01.2013, p. 37-47.

Research output: Contribution to journalArticle

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