Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy

Seyed Fazel Nabavi, Alistair J. Barber, Carmela Spagnuolo, Gian Luigi Russo, Maria Daglia, Seyed Mohammad Nabavi, Eduardo Sobarzo-Sánchez

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Abstract: Diabetic retinopathy is a microvascular complication of diabetes that is considered one of the leading causes of blindness among adults. More than 4.4 million people suffer from this disorder throughout the world. Growing evidence suggests that oxidative stress plays a crucial role in the pathophysiology of diabetic retinopathy. Nuclear factor erythroid 2-related factor 2 (Nrf2), a redox sensitive transcription factor, plays an essential protective role in regulating the physiological response to oxidative and electrophilic stress via regulation of multiple genes encoding antioxidant proteins and phase II detoxifying enzymes. Many studies suggest that dozens of natural compounds, including polyphenols, can supress oxidative stress and inflammation through targeting Nrf2 and consequently activating the antioxidant response element-related cytoprotective genes. Therefore, Nrf2 may provide a new therapeutic target for treatment of diabetic retinopathy. In the present article, we will focus on the role of Nrf2 in diabetic retinopathy and the ability of polyphenols to target Nrf2 as a therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)293-312
Number of pages20
JournalCritical Reviews in Clinical Laboratory Sciences
Volume53
Issue number5
DOIs
StatePublished - Sep 2 2016

Fingerprint

Oxidative stress
Polyphenols
Diabetic Retinopathy
Antioxidant Response Elements
Oxidative Stress
Gene encoding
Medical problems
Transcription Factors
Antioxidants
Genes
Diabetes Complications
Enzymes
Blindness
Therapeutics
Oxidation-Reduction
Proteins
Inflammation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Nabavi, Seyed Fazel ; Barber, Alistair J. ; Spagnuolo, Carmela ; Russo, Gian Luigi ; Daglia, Maria ; Nabavi, Seyed Mohammad ; Sobarzo-Sánchez, Eduardo. / Nrf2 as molecular target for polyphenols : A novel therapeutic strategy in diabetic retinopathy. In: Critical Reviews in Clinical Laboratory Sciences. 2016 ; Vol. 53, No. 5. pp. 293-312.
@article{d6bc4e738e014f9198c96b89a71439ca,
title = "Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy",
abstract = "Abstract: Diabetic retinopathy is a microvascular complication of diabetes that is considered one of the leading causes of blindness among adults. More than 4.4 million people suffer from this disorder throughout the world. Growing evidence suggests that oxidative stress plays a crucial role in the pathophysiology of diabetic retinopathy. Nuclear factor erythroid 2-related factor 2 (Nrf2), a redox sensitive transcription factor, plays an essential protective role in regulating the physiological response to oxidative and electrophilic stress via regulation of multiple genes encoding antioxidant proteins and phase II detoxifying enzymes. Many studies suggest that dozens of natural compounds, including polyphenols, can supress oxidative stress and inflammation through targeting Nrf2 and consequently activating the antioxidant response element-related cytoprotective genes. Therefore, Nrf2 may provide a new therapeutic target for treatment of diabetic retinopathy. In the present article, we will focus on the role of Nrf2 in diabetic retinopathy and the ability of polyphenols to target Nrf2 as a therapeutic strategy.",
author = "Nabavi, {Seyed Fazel} and Barber, {Alistair J.} and Carmela Spagnuolo and Russo, {Gian Luigi} and Maria Daglia and Nabavi, {Seyed Mohammad} and Eduardo Sobarzo-S{\'a}nchez",
year = "2016",
month = "9",
day = "2",
doi = "10.3109/10408363.2015.1129530",
language = "English (US)",
volume = "53",
pages = "293--312",
journal = "Critical Reviews in Clinical Laboratory Sciences",
issn = "1040-8363",
publisher = "Informa Healthcare",
number = "5",

}

Nrf2 as molecular target for polyphenols : A novel therapeutic strategy in diabetic retinopathy. / Nabavi, Seyed Fazel; Barber, Alistair J.; Spagnuolo, Carmela; Russo, Gian Luigi; Daglia, Maria; Nabavi, Seyed Mohammad; Sobarzo-Sánchez, Eduardo.

In: Critical Reviews in Clinical Laboratory Sciences, Vol. 53, No. 5, 02.09.2016, p. 293-312.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Nrf2 as molecular target for polyphenols

T2 - A novel therapeutic strategy in diabetic retinopathy

AU - Nabavi, Seyed Fazel

AU - Barber, Alistair J.

AU - Spagnuolo, Carmela

AU - Russo, Gian Luigi

AU - Daglia, Maria

AU - Nabavi, Seyed Mohammad

AU - Sobarzo-Sánchez, Eduardo

PY - 2016/9/2

Y1 - 2016/9/2

N2 - Abstract: Diabetic retinopathy is a microvascular complication of diabetes that is considered one of the leading causes of blindness among adults. More than 4.4 million people suffer from this disorder throughout the world. Growing evidence suggests that oxidative stress plays a crucial role in the pathophysiology of diabetic retinopathy. Nuclear factor erythroid 2-related factor 2 (Nrf2), a redox sensitive transcription factor, plays an essential protective role in regulating the physiological response to oxidative and electrophilic stress via regulation of multiple genes encoding antioxidant proteins and phase II detoxifying enzymes. Many studies suggest that dozens of natural compounds, including polyphenols, can supress oxidative stress and inflammation through targeting Nrf2 and consequently activating the antioxidant response element-related cytoprotective genes. Therefore, Nrf2 may provide a new therapeutic target for treatment of diabetic retinopathy. In the present article, we will focus on the role of Nrf2 in diabetic retinopathy and the ability of polyphenols to target Nrf2 as a therapeutic strategy.

AB - Abstract: Diabetic retinopathy is a microvascular complication of diabetes that is considered one of the leading causes of blindness among adults. More than 4.4 million people suffer from this disorder throughout the world. Growing evidence suggests that oxidative stress plays a crucial role in the pathophysiology of diabetic retinopathy. Nuclear factor erythroid 2-related factor 2 (Nrf2), a redox sensitive transcription factor, plays an essential protective role in regulating the physiological response to oxidative and electrophilic stress via regulation of multiple genes encoding antioxidant proteins and phase II detoxifying enzymes. Many studies suggest that dozens of natural compounds, including polyphenols, can supress oxidative stress and inflammation through targeting Nrf2 and consequently activating the antioxidant response element-related cytoprotective genes. Therefore, Nrf2 may provide a new therapeutic target for treatment of diabetic retinopathy. In the present article, we will focus on the role of Nrf2 in diabetic retinopathy and the ability of polyphenols to target Nrf2 as a therapeutic strategy.

UR - http://www.scopus.com/inward/record.url?scp=84961207101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961207101&partnerID=8YFLogxK

U2 - 10.3109/10408363.2015.1129530

DO - 10.3109/10408363.2015.1129530

M3 - Review article

C2 - 26926494

AN - SCOPUS:84961207101

VL - 53

SP - 293

EP - 312

JO - Critical Reviews in Clinical Laboratory Sciences

JF - Critical Reviews in Clinical Laboratory Sciences

SN - 1040-8363

IS - 5

ER -