Nucleic acid aptamers in cancer research, diagnosis and therapy

Haitao Ma, Jinping Liu, M. Monsur Ali, M. Arif Iftakher Mahmood, Louai Labanieh, Mengrou Lu, Samir M. Iqbal, Qun Zhang, Weian Zhao, Yuan Wan

Research output: Contribution to journalReview article

97 Citations (Scopus)

Abstract

Aptamers are single-stranded DNA or RNA oligomers, identified from a random sequence pool, with the ability to form unique and versatile tertiary structures that bind to cognate molecules with superior specificity. Their small size, excellent chemical stability and low immunogenicity enable them to rival antibodies in cancer imaging and therapy applications. Their facile chemical synthesis, versatility in structural design and engineering, and the ability for site-specific modifications with functional moieties make aptamers excellent recognition motifs for cancer biomarker discovery and detection. Moreover, aptamers can be selected or engineered to regulate cancer protein functions, as well as to guide anti-cancer drug design or screening. This review summarizes their applications in cancer, including cancer biomarker discovery and detection, cancer imaging, cancer therapy, and anti-cancer drug discovery. Although relevant applications are relatively new, the significant progress achieved has demonstrated that aptamers can be promising players in cancer research. This journal is

Original languageEnglish (US)
Pages (from-to)1240-1256
Number of pages17
JournalChemical Society Reviews
Volume44
Issue number5
DOIs
StatePublished - Mar 7 2015

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Nucleic Acids
Tumor Biomarkers
Structural design
Imaging techniques
Single-Stranded DNA
Chemical stability
Oligomers
Screening
RNA
Molecules
Antibodies
Pharmaceutical Preparations
Proteins
Drug Discovery

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Ma, H., Liu, J., Ali, M. M., Mahmood, M. A. I., Labanieh, L., Lu, M., ... Wan, Y. (2015). Nucleic acid aptamers in cancer research, diagnosis and therapy. Chemical Society Reviews, 44(5), 1240-1256. https://doi.org/10.1039/c4cs00357h
Ma, Haitao ; Liu, Jinping ; Ali, M. Monsur ; Mahmood, M. Arif Iftakher ; Labanieh, Louai ; Lu, Mengrou ; Iqbal, Samir M. ; Zhang, Qun ; Zhao, Weian ; Wan, Yuan. / Nucleic acid aptamers in cancer research, diagnosis and therapy. In: Chemical Society Reviews. 2015 ; Vol. 44, No. 5. pp. 1240-1256.
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Ma, H, Liu, J, Ali, MM, Mahmood, MAI, Labanieh, L, Lu, M, Iqbal, SM, Zhang, Q, Zhao, W & Wan, Y 2015, 'Nucleic acid aptamers in cancer research, diagnosis and therapy', Chemical Society Reviews, vol. 44, no. 5, pp. 1240-1256. https://doi.org/10.1039/c4cs00357h

Nucleic acid aptamers in cancer research, diagnosis and therapy. / Ma, Haitao; Liu, Jinping; Ali, M. Monsur; Mahmood, M. Arif Iftakher; Labanieh, Louai; Lu, Mengrou; Iqbal, Samir M.; Zhang, Qun; Zhao, Weian; Wan, Yuan.

In: Chemical Society Reviews, Vol. 44, No. 5, 07.03.2015, p. 1240-1256.

Research output: Contribution to journalReview article

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AU - Zhang, Qun

AU - Zhao, Weian

AU - Wan, Yuan

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Ma H, Liu J, Ali MM, Mahmood MAI, Labanieh L, Lu M et al. Nucleic acid aptamers in cancer research, diagnosis and therapy. Chemical Society Reviews. 2015 Mar 7;44(5):1240-1256. https://doi.org/10.1039/c4cs00357h