Nucleosome positioning and gene regulation

Advances through genomics

Cizhong Jiang, Benjamin Franklin Pugh

Research output: Contribution to journalReview article

608 Citations (Scopus)

Abstract

Knowing the precise locations of nucleosomes in a genome is key to understanding how genes are regulated. Recent 'next generation' ChIP-chip and ChIP-Seq technologies have accelerated our understanding of the basic principles of chromatin organization. Here we discuss what high-resolution genome-wide maps of nucleosome positions have taught us about how nucleosome positioning demarcates promoter regions and transcriptional start sites, and how the composition and structure of promoter nucleosomes facilitate or inhibit transcription. A detailed picture is starting to emerge of how diverse factors, including underlying DNA sequences and chromatin remodelling complexes, influence nucleosome positioning.

Original languageEnglish (US)
Pages (from-to)161-172
Number of pages12
JournalNature Reviews Genetics
Volume10
Issue number3
DOIs
StatePublished - Mar 1 2009

Fingerprint

Nucleosomes
Genomics
Genes
Genome
Chromatin Assembly and Disassembly
Genetic Promoter Regions
Chromatin
Technology

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

Cite this

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Nucleosome positioning and gene regulation : Advances through genomics. / Jiang, Cizhong; Pugh, Benjamin Franklin.

In: Nature Reviews Genetics, Vol. 10, No. 3, 01.03.2009, p. 161-172.

Research output: Contribution to journalReview article

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