Nucleosome structural studies

Song Tan, Curt A. Davey

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

Chromatin plays a fundamental role in eukaryotic genomic regulation, and the increasing awareness of the importance of epigenetic processes in human health and disease emphasizes the need for understanding the structure and function of the nucleosome. Recent advances in chromatin structural studies, including the first structures of nucleosomes containing the Widom 601 sequence and the structure of a chromatin protein-nucleosome assembly, have provided new insight into stretching of nucleosomal DNA, nucleosome positioning, binding of metal ions, drugs and therapeutic candidates to nucleosomes, and nucleosome recognition by nuclear proteins. These discoveries ensure promising future prospects for unravelling structural attributes of chromatin.

Original languageEnglish (US)
Pages (from-to)128-136
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2011

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Structural Biology

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