Nucleotide metabolism, oncogene-induced senescence and cancer

Katherine Aird, Rugang Zhang

Research output: Contribution to journalShort survey

42 Scopus citations

Abstract

Senescence is defined as a stable cell growth arrest. Oncogene-induced senescence (OIS) occurs when an activated oncogene is expressed in a normal cell. OIS acts as a bona fide tumor suppressor mechanism by driving stable growth arrest of cancer progenitor cells harboring the initial oncogenic hit. OIS is often characterized by aberrant DNA replication and the associated DNA damage response. Nucleotides, in particular deoxyribonucleotide triphosphates (dNTPs), are necessary for both DNA replication and repair. Imbalanced dNTP pools play a role in a number of human diseases, including during the early stages of cancer development. This review will highlight what is currently known about the role of decreased nucleotide metabolism in OIS, how nucleotide metabolism leads to transformation and tumor progression, and how this pathway can be targeted as a cancer therapeutic by inducing senescence of cancer cells.

Original languageEnglish (US)
Pages (from-to)204-210
Number of pages7
JournalCancer Letters
Volume356
Issue number2
DOIs
StatePublished - Jan 28 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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