Nucleotide sequence analysis of class II genes borne by mouse t chromosomes

M. Golubić, O. Budimir, R. Schoepfer, M. Kasahara, W. E. Mayer, F. Figueroa, J. Klein

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Five class II H-2 genes borne by t chromosomes were partially sequenced: [formula omitted] borne by the tTuw10 chromosome of EDY589 (H-2w2); [formula omitted] and [formula omitted] borne by the tTuw8 chromosome of CR0437 (H-2w57), as well as [formula omitted] and [formula omitted] borne by the tTuw7 chromosome of CR0435 (H-2w37). These genes are representatives of the three major groups of alleles found associated with t chromosomes. The sequenced part consisted of almost the entire exon 2 and the entire exon 3 coding for the first and the second domain of the β polypeptide chains, respectively. The sequence was compared with the published sequences of Aβ and Eβ alleles borne, by non-t chromosomes. The comparison revealed that the t-associated alleles are no more similar to one another than they are to the corresponding genes present on non-t chromosomes in laboratory mice. This divergence in the nucleotide sequence among the class II genes is interpreted as evidence that the t complex is very old.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalGenetical Research
Volume50
Issue number2
DOIs
StatePublished - Jan 1 1987

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MHC Class II Genes
Sequence Analysis
Chromosomes
Alleles
Exons
Genes
Peptides

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Golubić, M., Budimir, O., Schoepfer, R., Kasahara, M., Mayer, W. E., Figueroa, F., & Klein, J. (1987). Nucleotide sequence analysis of class II genes borne by mouse t chromosomes. Genetical Research, 50(2), 137-146. https://doi.org/10.1017/S0016672300023545
Golubić, M. ; Budimir, O. ; Schoepfer, R. ; Kasahara, M. ; Mayer, W. E. ; Figueroa, F. ; Klein, J. / Nucleotide sequence analysis of class II genes borne by mouse t chromosomes. In: Genetical Research. 1987 ; Vol. 50, No. 2. pp. 137-146.
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Golubić, M, Budimir, O, Schoepfer, R, Kasahara, M, Mayer, WE, Figueroa, F & Klein, J 1987, 'Nucleotide sequence analysis of class II genes borne by mouse t chromosomes', Genetical Research, vol. 50, no. 2, pp. 137-146. https://doi.org/10.1017/S0016672300023545

Nucleotide sequence analysis of class II genes borne by mouse t chromosomes. / Golubić, M.; Budimir, O.; Schoepfer, R.; Kasahara, M.; Mayer, W. E.; Figueroa, F.; Klein, J.

In: Genetical Research, Vol. 50, No. 2, 01.01.1987, p. 137-146.

Research output: Contribution to journalArticle

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Golubić M, Budimir O, Schoepfer R, Kasahara M, Mayer WE, Figueroa F et al. Nucleotide sequence analysis of class II genes borne by mouse t chromosomes. Genetical Research. 1987 Jan 1;50(2):137-146. https://doi.org/10.1017/S0016672300023545