Numerical prediction of the focal sites of ozone-induced tissue injury in the respiratory tract

B. Keshavarzi, J. Ultman, A. Borhan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Numerical simulations of ozone transport and uptake in an anatomically-accurate model of the respiratory tract of a Rhesus monkey were performed. The model geometry was created using three-dimensional reconstruction of MRI images of the respiratory tract, including the larynx and the first thirteen generations of the tracheobronchial tree. An unstructured mesh was generated for the resulting structure, and three-dimensional flow and concentration distributions were obtained through numerical solution of the Navier-Stokes, continuity, and species convection-diffusion equations. A quasi-steady diffusion-reaction model was used to account for the interaction between O3 and endogenous substrates in the respiratory tract lining fluid. Hotspots of O3 flux on the walls were identified for steady inspiratory flow under quiet breathing conditions.

Original languageEnglish (US)
Title of host publicationModelling in Medicine and Biology VIII
Pages123-132
Number of pages10
DOIs
StatePublished - 2009
Event8th International Conference on Modelling in Medicine and Biology, BIOMED 2009 - Crete, Greece
Duration: May 26 2009May 28 2009

Publication series

NameWIT Transactions on Biomedicine and Health
Volume13
ISSN (Print)1743-3525

Other

Other8th International Conference on Modelling in Medicine and Biology, BIOMED 2009
CountryGreece
CityCrete
Period5/26/095/28/09

All Science Journal Classification (ASJC) codes

  • Modeling and Simulation
  • Biomedical Engineering
  • Computer Science Applications
  • Public Health, Environmental and Occupational Health

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