Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Citations (Scopus)

Abstract

Diets rich in ω3 polyunsaturated fatty acids (ω3-PUFAs) such as alpha-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid are associated with decreased incidence and severity of several chronic diseases including cardiovascular disease (CVD) and cancer. At least some of the beneficial effects of these dietary fatty acids are via metabolites such as prostaglandins, leukotrienes, thromboxanes, and resolvins. The effects of ω3-PUFAs are in contrast to those of fatty acids with virtually identical structures, such as the ω6-PUFAs linoleic acid and arachidonic acid, and their corresponding metabolites. The purpose of this chapter is to discuss both the nutrigenomics (nutrient-gene interactions) and nutrigenetics (genetic variation in nutrition) of dietary fatty acids with a focus on the ω3-PUFAs (Gebauer et al., 2007 1 ). Important in the biological response for these fatty acids or their metabolites are cognate receptors that are able to regulate gene expression and coordinately affect metabolic or signaling pathways associated with CVD and cancer. Four nuclear receptor (NR) subfamilies will be emphasized as receptors that respond to dietary and endogenous ligands: (1) peroxisome proliferator-activated receptors, (2) retinoid X receptors, (3) liver X receptors, and (4) farnesoid X receptor. In addition to the different responses elicited by varying structures of fatty acids, responses may vary because of genetic variation in enzymes that metabolize ω3- and ω6 fatty acids or that respond to them. In particular, polymorphisms in the fatty acid desaturases and the aforementioned NRs contribute to the complexity of nutritional effects seen with ω3-PUFAs. Following a brief introduction to the health benefits of ω3-PUFAs, the regulation of gene expression by these dietary fatty acids via NRs will be characterized. Subsequently, the effects of single-nucleotide polymorphisms (SNPs) in key enzymes involved in the metabolism and response to ω3-PUFAs will be described. An outline of the events to be explored is shown in Fig. 1. Understanding the nutrigenomics and nutrigenetics of dietary fatty acids is key to understanding the etiology, as well as prevention, of critically important human diseases including CVD and cancer.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages75-112
Number of pages38
DOIs
StatePublished - Jan 1 2012

Publication series

NameProgress in Molecular Biology and Translational Science
Volume108
ISSN (Print)1877-1173

Fingerprint

Nutrigenomics
Unsaturated Fatty Acids
Fatty Acids
Cardiovascular Diseases
Fatty Acid Desaturases
Retinoid X Receptors
Neoplasms
Peroxisome Proliferator-Activated Receptors
alpha-Linolenic Acid
Eicosapentaenoic Acid
Docosahexaenoic Acids
Leukotrienes
Thromboxanes
Gene Expression Regulation
Insurance Benefits
Linoleic Acid
Enzymes
Cytoplasmic and Nuclear Receptors
Arachidonic Acid
Prostaglandins

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

Cite this

Vanden Heuvel, J. P. (2012). Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids. In Progress in Molecular Biology and Translational Science (pp. 75-112). (Progress in Molecular Biology and Translational Science; Vol. 108). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-398397-8.00004-6
Vanden Heuvel, John Patrick. / Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids. Progress in Molecular Biology and Translational Science. Elsevier B.V., 2012. pp. 75-112 (Progress in Molecular Biology and Translational Science).
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Vanden Heuvel, JP 2012, Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids. in Progress in Molecular Biology and Translational Science. Progress in Molecular Biology and Translational Science, vol. 108, Elsevier B.V., pp. 75-112. https://doi.org/10.1016/B978-0-12-398397-8.00004-6

Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids. / Vanden Heuvel, John Patrick.

Progress in Molecular Biology and Translational Science. Elsevier B.V., 2012. p. 75-112 (Progress in Molecular Biology and Translational Science; Vol. 108).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Vanden Heuvel JP. Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids. In Progress in Molecular Biology and Translational Science. Elsevier B.V. 2012. p. 75-112. (Progress in Molecular Biology and Translational Science). https://doi.org/10.1016/B978-0-12-398397-8.00004-6