Nutritional control of HIV-AIDS- A case for selenium

Parisa Kalantari, Hema Vunta, Umamaheswari D. Palempalli, C. Channa Reddy, Andrew J. Henderson, Kumble Sandeep Prabhu

Research output: Contribution to journalShort survey

Abstract

Selenium (Se) is a micronutrient that is incorporated into proteins. Some of the selenoenzymes such as GPXs and thioredoxin reductases exhibit glutathione peroxidase-dependent activities towards organic and inorganic peroxides. Thus, selenoenzymes play a pivotal role in mitigating oxidative stress caused by accumulation of peroxides. In this respect, selenoproteins may interfere with the transcription-driven by oxidative stress-dependent signaling mechanisms to influence the expression of redox sensitive genes, including inflammatory cytokines and HIV provirus. Several epidemiological studies support our view that Se supplementation affects transcription of HIV; however, the underlying mechanism is not elucidated. In this mini review, we ccnsider the relationship between Se and HIV and propose possible mechanisms by which Se controls HIV transcription.

Original languageEnglish (US)
Pages (from-to)195-201
Number of pages7
JournalAmerican Journal of Infectious Diseases
Volume3
Issue number4
DOIs
StatePublished - Jan 1 2007

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Selenium
Acquired Immunodeficiency Syndrome
HIV
Peroxides
Oxidative Stress
Selenoproteins
Thioredoxin-Disulfide Reductase
Proviruses
Micronutrients
Glutathione Peroxidase
Oxidation-Reduction
Epidemiologic Studies
Cytokines
Genes
Proteins

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

Cite this

Kalantari, P., Vunta, H., Palempalli, U. D., Reddy, C. C., Henderson, A. J., & Prabhu, K. S. (2007). Nutritional control of HIV-AIDS- A case for selenium. American Journal of Infectious Diseases, 3(4), 195-201. https://doi.org/10.3844/ajidsp.2007.195.201
Kalantari, Parisa ; Vunta, Hema ; Palempalli, Umamaheswari D. ; Reddy, C. Channa ; Henderson, Andrew J. ; Prabhu, Kumble Sandeep. / Nutritional control of HIV-AIDS- A case for selenium. In: American Journal of Infectious Diseases. 2007 ; Vol. 3, No. 4. pp. 195-201.
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Kalantari, P, Vunta, H, Palempalli, UD, Reddy, CC, Henderson, AJ & Prabhu, KS 2007, 'Nutritional control of HIV-AIDS- A case for selenium', American Journal of Infectious Diseases, vol. 3, no. 4, pp. 195-201. https://doi.org/10.3844/ajidsp.2007.195.201

Nutritional control of HIV-AIDS- A case for selenium. / Kalantari, Parisa; Vunta, Hema; Palempalli, Umamaheswari D.; Reddy, C. Channa; Henderson, Andrew J.; Prabhu, Kumble Sandeep.

In: American Journal of Infectious Diseases, Vol. 3, No. 4, 01.01.2007, p. 195-201.

Research output: Contribution to journalShort survey

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T1 - Nutritional control of HIV-AIDS- A case for selenium

AU - Kalantari, Parisa

AU - Vunta, Hema

AU - Palempalli, Umamaheswari D.

AU - Reddy, C. Channa

AU - Henderson, Andrew J.

AU - Prabhu, Kumble Sandeep

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