Obesity and sleep disturbances

Jacqueline M. Danisi, Julio Fernandez-Mendoza, Alexandros Vgontzas, Edward Bixler

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

34 Scopus citations


The global obesity epidemic is rising due to unmodifiable and modifiable causes, one of them being inadequate sleep. Although shortened sleep duration and poor sleep have been shown to lead to a greater incidence of obesity, nonobese chronic insomniacs do not follow this trend. This reveals that not all types of inadequate sleep lead to weight gain and onset of subsequent obesity. In addition, OSA patients are shown to gain weight, even after using continuous positive airway pressure. Obesity is the main risk factor for OSA, which aids in its progression due to the increase in the accumulation of higher plasma proinflammatory load. This increase in proinflammatory cytokines plays a role in the development of adverse cardiometabolic outcomes. In turn, this metabolic dysregulation may lead to the development of daytime sleepiness.
Original languageEnglish (US)
Title of host publicationThe Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle
ISBN (Print) 978-0-12-816430-3
StatePublished - 2019


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