Obesity, diabetes, and risk of Parkinson's disease

Natalia Palacios, Xiang Gao, Marjorie L. Mccullough, Eric J. Jacobs, Alpa V. Patel, Tinisha Mayo, Michael A. Schwarzschild, Alberto Ascherio

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The aim of this work was to investigate whether obesity and diabetes are related to risk of Parkinson's disease. We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of Parkinson's disease (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted Parkinson's disease risk. Relative risk comparing individuals with a baseline body mass index of ≥30 to those with a body mass index <23 was 1.00 (95% confidence interval: 0.75, 1.34; P trend: 0.79), and that comparing individuals with a waist circumference in the top category (≥40.3 inches in men and ≥35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% confidence interval: 0.95, 1.93; P trend: 0.08). History of diabetes was not significantly associated with Parkinson's disease risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; P heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with Parkinson's disease risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)2253-2259
Number of pages7
JournalMovement Disorders
Volume26
Issue number12
DOIs
StatePublished - Oct 1 2011

Fingerprint

Parkinson Disease
Obesity
Waist Circumference
Body Mass Index
Confidence Intervals
Weights and Measures
Proportional Hazards Models
Medical Records
Smoking
Neoplasms

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Palacios, N., Gao, X., Mccullough, M. L., Jacobs, E. J., Patel, A. V., Mayo, T., ... Ascherio, A. (2011). Obesity, diabetes, and risk of Parkinson's disease. Movement Disorders, 26(12), 2253-2259. https://doi.org/10.1002/mds.23855
Palacios, Natalia ; Gao, Xiang ; Mccullough, Marjorie L. ; Jacobs, Eric J. ; Patel, Alpa V. ; Mayo, Tinisha ; Schwarzschild, Michael A. ; Ascherio, Alberto. / Obesity, diabetes, and risk of Parkinson's disease. In: Movement Disorders. 2011 ; Vol. 26, No. 12. pp. 2253-2259.
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Palacios, N, Gao, X, Mccullough, ML, Jacobs, EJ, Patel, AV, Mayo, T, Schwarzschild, MA & Ascherio, A 2011, 'Obesity, diabetes, and risk of Parkinson's disease', Movement Disorders, vol. 26, no. 12, pp. 2253-2259. https://doi.org/10.1002/mds.23855

Obesity, diabetes, and risk of Parkinson's disease. / Palacios, Natalia; Gao, Xiang; Mccullough, Marjorie L.; Jacobs, Eric J.; Patel, Alpa V.; Mayo, Tinisha; Schwarzschild, Michael A.; Ascherio, Alberto.

In: Movement Disorders, Vol. 26, No. 12, 01.10.2011, p. 2253-2259.

Research output: Contribution to journalArticle

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Palacios N, Gao X, Mccullough ML, Jacobs EJ, Patel AV, Mayo T et al. Obesity, diabetes, and risk of Parkinson's disease. Movement Disorders. 2011 Oct 1;26(12):2253-2259. https://doi.org/10.1002/mds.23855