Observation of an amplified isotope effect during chlorination of 1-methylpyrrole. Evidence for rate determining deprotonation of the σ-complex

Michael De Rosa, Manuel Marquez

Research output: Contribution to journalArticle

4 Scopus citations


Observation of an amplified isotope effect to the value of 19.10 indicated that there were two kinetically significant proton transfers and deprotonation of the σ-complex was the rate determining step.

Original languageEnglish (US)
Pages (from-to)1466-1467
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number19
Publication statusPublished - Jan 1 1989


All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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