Observational study of cerebral hemodynamics during dopamine treatment in hypotensive ELBW infants on the first day of life

M. H. Lightburn, C. H. Gauss, D. K. Williams, J. R. Kaiser

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objective:To evaluate cerebral hemodynamics during dopamine treatment in hypotensive (mean arterial blood pressure (MABP)<gestational age) extremely low birth weight (ELBW) infants.Study Design:Continuous monitoring of cerebral blood flow velocity (CBFv), MABP and PCO 2 was performed in hypotensive ELBW infants on the first day of life, beginning with an ∼15-min baseline reading and continued during advancing dopamine infusion until MABP was optimized. Physiological variables and CBFv reactivity were compared before and after MABP was optimized.Result:Fifteen hypotensive ELBW infants (625±174 g; 24 (23 to 24.8) weeks) were studied. Mean CBFv increased from 10.9±3.7 to 15.7±5.7 cm s -1 (P=0.001) simultaneously as MABP increased from 22.3±2.8 to 35.2±9.7 mm Hg (P<0.001). Mean CBFv reactivity (95% confidence interval (CI)) was 3.9 (1.6 to 6.2) %mm Hg -1. Nine infants died and/or developed severe intraventricular hemorrhage (IVH).Conclusion:Mean CBFv increased pressure-passively as MABP was optimized by dopamine treatment in very sick hypotensive ELBW infants on the first day of life.

Original languageEnglish (US)
Pages (from-to)698-702
Number of pages5
JournalJournal of Perinatology
Volume33
Issue number9
DOIs
StatePublished - Sep 1 2013

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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