Observing the sleep-wake regulatory system to improve prediction of seizures

M. Sedigh-Sarvestani, Bruce Gluckman

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

We describe our ongoing efforts to understand the dynamics of the sleep-wake regulatory system to improve seizure prediction. Although mathematical models of its dynamics have been developed, the activity of this system is difficult to observe directly. Therefore we have developed a data assimilation framework that combines sparse measurements of the sleep-wake regulatory system together with a mathematical model of its dynamics to estimate the unmeasured variables. This toolset will allow us to understand the interaction between modulators of the state-of-vigilance and seizure susceptibility and may provide meaningful indicators of an impending seizure.

Original languageEnglish (US)
Title of host publicationRecent Advance in Predicting and Preventing Epileptic Sezures
PublisherWorld Scientific Publishing Co.
Pages264-277
Number of pages14
ISBN (Electronic)9789814525350
ISBN (Print)9789814525343
DOIs
StatePublished - Jan 1 2013

Fingerprint

Sleep
Seizures
Theoretical Models
Mathematical models
Modulators

All Science Journal Classification (ASJC) codes

  • Computer Science(all)
  • Medicine(all)
  • Neuroscience(all)

Cite this

Sedigh-Sarvestani, M., & Gluckman, B. (2013). Observing the sleep-wake regulatory system to improve prediction of seizures. In Recent Advance in Predicting and Preventing Epileptic Sezures (pp. 264-277). World Scientific Publishing Co.. https://doi.org/10.1142/9789814525350_0020
Sedigh-Sarvestani, M. ; Gluckman, Bruce. / Observing the sleep-wake regulatory system to improve prediction of seizures. Recent Advance in Predicting and Preventing Epileptic Sezures. World Scientific Publishing Co., 2013. pp. 264-277
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Sedigh-Sarvestani, M & Gluckman, B 2013, Observing the sleep-wake regulatory system to improve prediction of seizures. in Recent Advance in Predicting and Preventing Epileptic Sezures. World Scientific Publishing Co., pp. 264-277. https://doi.org/10.1142/9789814525350_0020

Observing the sleep-wake regulatory system to improve prediction of seizures. / Sedigh-Sarvestani, M.; Gluckman, Bruce.

Recent Advance in Predicting and Preventing Epileptic Sezures. World Scientific Publishing Co., 2013. p. 264-277.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Sedigh-Sarvestani M, Gluckman B. Observing the sleep-wake regulatory system to improve prediction of seizures. In Recent Advance in Predicting and Preventing Epileptic Sezures. World Scientific Publishing Co. 2013. p. 264-277 https://doi.org/10.1142/9789814525350_0020