Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome: results from a randomized trial

Bo Zhang, Daimin Wei, Richard Legro, Yuhua Shi, Jing Li, Lin Zhang, Yan Hong, Gang Sun, Ting Zhang, Weiping Li, Zi Jiang Chen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To evaluate the effect of frozen embryo transfer on maternal and neonatal complications of singleton and twin pregnancies compared with fresh embryo transfer in women with polycystic ovary syndrome (PCOS). Design: A secondary analysis of a multicenter, randomized, controlled trial comparing live birth after frozen vs. fresh embryo transfer (FreFro-PCOS). Setting: Reproductive medicine centers. Patient(s): A total of 1,508 patients with a diagnosis of PCOS who were undergoing IVF were enrolled. Intervention(s): On day of oocyte retrieval, eligible patients were randomized to the fresh or frozen embryo transfer groups. Up to two embryos were transferred in both groups. All pregnancies were followed up until delivery. Main Outcome Measure(s): Gestational diabetes mellitus, pre-eclampsia, preterm birth, small for gestational age, and large for gestational age. Result(s): The risks of gestational diabetes mellitus, preterm birth, and small for gestational age were comparable between the frozen and fresh embryo transfer groups in both singleton and twin births. However, singleton infants born after frozen embryo transfer were more likely to be large for gestational age (25.2% vs. 17.5%; relative risk 1.44, 95% confidence interval 1.01–2.07, P=.044) than those born after fresh embryo transfer. Twin pregnancy after frozen embryo transfer had a higher risk of pre-eclampsia (12.0% vs. 2.8%; relative risk 4.31, 95% confidence interval 1.27–14.58, P=.009) than those after fresh embryo transfer. Conclusion(s): In women with PCOS, frozen embryo transfer resulted in an increased risk of large for gestational age in singleton pregnancy and a higher risk of pre-eclampsia in twin pregnancy. Clinical Trial Registration Number: NCT01841528.

Original languageEnglish (US)
Pages (from-to)324-329
Number of pages6
JournalFertility and sterility
Volume109
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Polycystic Ovary Syndrome
Embryo Transfer
Obstetrics
Gestational Age
Twin Pregnancy
Pre-Eclampsia
Gestational Diabetes
Premature Birth
Confidence Intervals
Reproductive Medicine
Oocyte Retrieval
High-Risk Pregnancy
Live Birth
Embryonic Structures
Randomized Controlled Trials
Mothers
Outcome Assessment (Health Care)
Clinical Trials
Parturition
Pregnancy

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Zhang, Bo ; Wei, Daimin ; Legro, Richard ; Shi, Yuhua ; Li, Jing ; Zhang, Lin ; Hong, Yan ; Sun, Gang ; Zhang, Ting ; Li, Weiping ; Chen, Zi Jiang. / Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome : results from a randomized trial. In: Fertility and sterility. 2018 ; Vol. 109, No. 2. pp. 324-329.
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abstract = "Objective: To evaluate the effect of frozen embryo transfer on maternal and neonatal complications of singleton and twin pregnancies compared with fresh embryo transfer in women with polycystic ovary syndrome (PCOS). Design: A secondary analysis of a multicenter, randomized, controlled trial comparing live birth after frozen vs. fresh embryo transfer (FreFro-PCOS). Setting: Reproductive medicine centers. Patient(s): A total of 1,508 patients with a diagnosis of PCOS who were undergoing IVF were enrolled. Intervention(s): On day of oocyte retrieval, eligible patients were randomized to the fresh or frozen embryo transfer groups. Up to two embryos were transferred in both groups. All pregnancies were followed up until delivery. Main Outcome Measure(s): Gestational diabetes mellitus, pre-eclampsia, preterm birth, small for gestational age, and large for gestational age. Result(s): The risks of gestational diabetes mellitus, preterm birth, and small for gestational age were comparable between the frozen and fresh embryo transfer groups in both singleton and twin births. However, singleton infants born after frozen embryo transfer were more likely to be large for gestational age (25.2{\%} vs. 17.5{\%}; relative risk 1.44, 95{\%} confidence interval 1.01–2.07, P=.044) than those born after fresh embryo transfer. Twin pregnancy after frozen embryo transfer had a higher risk of pre-eclampsia (12.0{\%} vs. 2.8{\%}; relative risk 4.31, 95{\%} confidence interval 1.27–14.58, P=.009) than those after fresh embryo transfer. Conclusion(s): In women with PCOS, frozen embryo transfer resulted in an increased risk of large for gestational age in singleton pregnancy and a higher risk of pre-eclampsia in twin pregnancy. Clinical Trial Registration Number: NCT01841528.",
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Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome : results from a randomized trial. / Zhang, Bo; Wei, Daimin; Legro, Richard; Shi, Yuhua; Li, Jing; Zhang, Lin; Hong, Yan; Sun, Gang; Zhang, Ting; Li, Weiping; Chen, Zi Jiang.

In: Fertility and sterility, Vol. 109, No. 2, 01.02.2018, p. 324-329.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome

T2 - results from a randomized trial

AU - Zhang, Bo

AU - Wei, Daimin

AU - Legro, Richard

AU - Shi, Yuhua

AU - Li, Jing

AU - Zhang, Lin

AU - Hong, Yan

AU - Sun, Gang

AU - Zhang, Ting

AU - Li, Weiping

AU - Chen, Zi Jiang

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N2 - Objective: To evaluate the effect of frozen embryo transfer on maternal and neonatal complications of singleton and twin pregnancies compared with fresh embryo transfer in women with polycystic ovary syndrome (PCOS). Design: A secondary analysis of a multicenter, randomized, controlled trial comparing live birth after frozen vs. fresh embryo transfer (FreFro-PCOS). Setting: Reproductive medicine centers. Patient(s): A total of 1,508 patients with a diagnosis of PCOS who were undergoing IVF were enrolled. Intervention(s): On day of oocyte retrieval, eligible patients were randomized to the fresh or frozen embryo transfer groups. Up to two embryos were transferred in both groups. All pregnancies were followed up until delivery. Main Outcome Measure(s): Gestational diabetes mellitus, pre-eclampsia, preterm birth, small for gestational age, and large for gestational age. Result(s): The risks of gestational diabetes mellitus, preterm birth, and small for gestational age were comparable between the frozen and fresh embryo transfer groups in both singleton and twin births. However, singleton infants born after frozen embryo transfer were more likely to be large for gestational age (25.2% vs. 17.5%; relative risk 1.44, 95% confidence interval 1.01–2.07, P=.044) than those born after fresh embryo transfer. Twin pregnancy after frozen embryo transfer had a higher risk of pre-eclampsia (12.0% vs. 2.8%; relative risk 4.31, 95% confidence interval 1.27–14.58, P=.009) than those after fresh embryo transfer. Conclusion(s): In women with PCOS, frozen embryo transfer resulted in an increased risk of large for gestational age in singleton pregnancy and a higher risk of pre-eclampsia in twin pregnancy. Clinical Trial Registration Number: NCT01841528.

AB - Objective: To evaluate the effect of frozen embryo transfer on maternal and neonatal complications of singleton and twin pregnancies compared with fresh embryo transfer in women with polycystic ovary syndrome (PCOS). Design: A secondary analysis of a multicenter, randomized, controlled trial comparing live birth after frozen vs. fresh embryo transfer (FreFro-PCOS). Setting: Reproductive medicine centers. Patient(s): A total of 1,508 patients with a diagnosis of PCOS who were undergoing IVF were enrolled. Intervention(s): On day of oocyte retrieval, eligible patients were randomized to the fresh or frozen embryo transfer groups. Up to two embryos were transferred in both groups. All pregnancies were followed up until delivery. Main Outcome Measure(s): Gestational diabetes mellitus, pre-eclampsia, preterm birth, small for gestational age, and large for gestational age. Result(s): The risks of gestational diabetes mellitus, preterm birth, and small for gestational age were comparable between the frozen and fresh embryo transfer groups in both singleton and twin births. However, singleton infants born after frozen embryo transfer were more likely to be large for gestational age (25.2% vs. 17.5%; relative risk 1.44, 95% confidence interval 1.01–2.07, P=.044) than those born after fresh embryo transfer. Twin pregnancy after frozen embryo transfer had a higher risk of pre-eclampsia (12.0% vs. 2.8%; relative risk 4.31, 95% confidence interval 1.27–14.58, P=.009) than those after fresh embryo transfer. Conclusion(s): In women with PCOS, frozen embryo transfer resulted in an increased risk of large for gestational age in singleton pregnancy and a higher risk of pre-eclampsia in twin pregnancy. Clinical Trial Registration Number: NCT01841528.

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