Obstructive apnea during sleep is associated with peripheral vasoconstriction

Virginia A. Imadojemu, Kevin Gleeson, Kristen S. Gray, Lawrence I. Sinoway, Urs A. Leuenberger

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Obstructive apnea during sleep is associated with a substantial transient blood pressure elevation. The mechanism of this pressor response is unclear. In this study we measured muscle sympathetic nerve activity (MSNA), mean arterial pressure (Psa), and mean limb blood velocity as an index of blood flow (MBV, Doppler) and calculated changes in limb vascular resistance during and after apneas during both wakefulness and sleep in patients with the obstructive sleep apnea syndrome. Immediately postapnea during sleep Psa increased significantly compared with the earlier stages of apnea and this was preceded by a rise of MSNA (n = 5). In contrast to blood pressure, MBV remained unchanged. Because resistance = blood pressure/blood flow, limb vascular resistance increased by 29 ± 8% from late apnea to postapnea (n = 7, p < 0.002). Voluntary breathhold maneuvers during room air exposure evoked similar responses (n = 10). Supplemental oxygen administered via nonrebreather face mask attenuated the MSNA and vasoconstrictor responses to obstructive (n = 2) and voluntary apneas (n = 10). Our data suggest that obstructive apneas in patients with the obstructive apnea syndrome are accompanied by transient limb vasoconstriction. This vasoconstrictor response appears to be, at least in part, mediated by the sympathetic nervous system and may be linked to hypoxia.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalAmerican journal of respiratory and critical care medicine
Volume165
Issue number1
DOIs
StatePublished - Jan 1 2002

Fingerprint

Obstructive Sleep Apnea
Apnea
Vasoconstriction
Extremities
Vasoconstrictor Agents
Blood Pressure
Vascular Resistance
Muscles
Sleep
Wakefulness
Sympathetic Nervous System
Masks
Arterial Pressure
Air
Oxygen

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

@article{1c3a42fd0aa44741a445d1fc9454f6e2,
title = "Obstructive apnea during sleep is associated with peripheral vasoconstriction",
abstract = "Obstructive apnea during sleep is associated with a substantial transient blood pressure elevation. The mechanism of this pressor response is unclear. In this study we measured muscle sympathetic nerve activity (MSNA), mean arterial pressure (Psa), and mean limb blood velocity as an index of blood flow (MBV, Doppler) and calculated changes in limb vascular resistance during and after apneas during both wakefulness and sleep in patients with the obstructive sleep apnea syndrome. Immediately postapnea during sleep Psa increased significantly compared with the earlier stages of apnea and this was preceded by a rise of MSNA (n = 5). In contrast to blood pressure, MBV remained unchanged. Because resistance = blood pressure/blood flow, limb vascular resistance increased by 29 ± 8{\%} from late apnea to postapnea (n = 7, p < 0.002). Voluntary breathhold maneuvers during room air exposure evoked similar responses (n = 10). Supplemental oxygen administered via nonrebreather face mask attenuated the MSNA and vasoconstrictor responses to obstructive (n = 2) and voluntary apneas (n = 10). Our data suggest that obstructive apneas in patients with the obstructive apnea syndrome are accompanied by transient limb vasoconstriction. This vasoconstrictor response appears to be, at least in part, mediated by the sympathetic nervous system and may be linked to hypoxia.",
author = "Imadojemu, {Virginia A.} and Kevin Gleeson and Gray, {Kristen S.} and Sinoway, {Lawrence I.} and Leuenberger, {Urs A.}",
year = "2002",
month = "1",
day = "1",
doi = "10.1164/ajrccm.165.1.2009062",
language = "English (US)",
volume = "165",
pages = "61--66",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "1",

}

Obstructive apnea during sleep is associated with peripheral vasoconstriction. / Imadojemu, Virginia A.; Gleeson, Kevin; Gray, Kristen S.; Sinoway, Lawrence I.; Leuenberger, Urs A.

In: American journal of respiratory and critical care medicine, Vol. 165, No. 1, 01.01.2002, p. 61-66.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Obstructive apnea during sleep is associated with peripheral vasoconstriction

AU - Imadojemu, Virginia A.

AU - Gleeson, Kevin

AU - Gray, Kristen S.

AU - Sinoway, Lawrence I.

AU - Leuenberger, Urs A.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Obstructive apnea during sleep is associated with a substantial transient blood pressure elevation. The mechanism of this pressor response is unclear. In this study we measured muscle sympathetic nerve activity (MSNA), mean arterial pressure (Psa), and mean limb blood velocity as an index of blood flow (MBV, Doppler) and calculated changes in limb vascular resistance during and after apneas during both wakefulness and sleep in patients with the obstructive sleep apnea syndrome. Immediately postapnea during sleep Psa increased significantly compared with the earlier stages of apnea and this was preceded by a rise of MSNA (n = 5). In contrast to blood pressure, MBV remained unchanged. Because resistance = blood pressure/blood flow, limb vascular resistance increased by 29 ± 8% from late apnea to postapnea (n = 7, p < 0.002). Voluntary breathhold maneuvers during room air exposure evoked similar responses (n = 10). Supplemental oxygen administered via nonrebreather face mask attenuated the MSNA and vasoconstrictor responses to obstructive (n = 2) and voluntary apneas (n = 10). Our data suggest that obstructive apneas in patients with the obstructive apnea syndrome are accompanied by transient limb vasoconstriction. This vasoconstrictor response appears to be, at least in part, mediated by the sympathetic nervous system and may be linked to hypoxia.

AB - Obstructive apnea during sleep is associated with a substantial transient blood pressure elevation. The mechanism of this pressor response is unclear. In this study we measured muscle sympathetic nerve activity (MSNA), mean arterial pressure (Psa), and mean limb blood velocity as an index of blood flow (MBV, Doppler) and calculated changes in limb vascular resistance during and after apneas during both wakefulness and sleep in patients with the obstructive sleep apnea syndrome. Immediately postapnea during sleep Psa increased significantly compared with the earlier stages of apnea and this was preceded by a rise of MSNA (n = 5). In contrast to blood pressure, MBV remained unchanged. Because resistance = blood pressure/blood flow, limb vascular resistance increased by 29 ± 8% from late apnea to postapnea (n = 7, p < 0.002). Voluntary breathhold maneuvers during room air exposure evoked similar responses (n = 10). Supplemental oxygen administered via nonrebreather face mask attenuated the MSNA and vasoconstrictor responses to obstructive (n = 2) and voluntary apneas (n = 10). Our data suggest that obstructive apneas in patients with the obstructive apnea syndrome are accompanied by transient limb vasoconstriction. This vasoconstrictor response appears to be, at least in part, mediated by the sympathetic nervous system and may be linked to hypoxia.

UR - http://www.scopus.com/inward/record.url?scp=0036140888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036140888&partnerID=8YFLogxK

U2 - 10.1164/ajrccm.165.1.2009062

DO - 10.1164/ajrccm.165.1.2009062

M3 - Article

C2 - 11779731

AN - SCOPUS:0036140888

VL - 165

SP - 61

EP - 66

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 1

ER -