Occupationally Related Nickel Reactions: A Retrospective Analysis of the North American Contact Dermatitis Group Data 1998-2016

Erin M. Warshaw, Jamie P. Schlarbaum, Joel G. DeKoven, Jonathan I. Silverberg, Kathryn A. Zug, James Marks, Donald V. Belsito, Toby Mathias, Margo J. Reeder, Amber R. Atwater, Howard I. Maibach, Denis Sasseville, Matthew J. Zirwas, Anthony F. Fransway, Melanie D. Pratt, Vincent A. DeLeo, Joseph F. Fowler, James S. Taylor

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The epidemiology of nickel allergy in occupational settings is not well understood. OBJECTIVE: The aim of the study was to characterize occupationally related nickel allergy (ORNA). METHODS: This is a retrospective cross-sectional analysis of 44,378 patients patch tested by the North American Contact Dermatitis Group from 1998 to 2016. Characteristics of individuals with ORNA were compared with those with non-ORNA (NORNA). RESULTS: A total of 7928 (18.2%) individuals were positive to nickel sulfate 2.5%. Two hundred sixty-eight (3.4%) had ORNA. As compared with NORNA, ORNA was statistically associated with the male sex (41.0% vs 12.9%, P < 0.001), a diagnosis of irritant contact dermatitis (22.4% vs 12.0%, P < 0.001), and no history of eczema (81.7% vs 75.7%, P = 0.0217). The most common sites of ORNA dermatitis were hand (39.9%) and arm (18.1%), which were significantly more common than in NORNA (P < 0.0001). Sixteen industry categories and 22 occupation categories were identified for ORNA; the most common industries were durable goods manufacturing (24.6%) and personal services (15.7%), and the most frequent occupations were hairdressers/cosmetologists/barbers (14.3%), machine operators (9.3%), and health care workers (7.1%). Overall 30% of ORNA occupations were in metalworking. Of 215 ORNA sources identified, instruments/phones/other equipment (16.3%), vehicles/machinery (15.8%), and tools (15.3%) were the most common. CONCLUSIONS: Occupational nickel allergy is distinct from nonoccupational nickel allergy.

Original languageEnglish (US)
Pages (from-to)306-313
Number of pages8
JournalDermatitis : contact, atopic, occupational, drug
Volume30
Issue number5
DOIs
StatePublished - Sep 1 2019

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Contact Dermatitis
Nickel
Hypersensitivity
Occupations
Industry
Irritant Dermatitis
Eczema
Dermatitis
Epidemiology
Arm
Hand
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology

Cite this

Warshaw, Erin M. ; Schlarbaum, Jamie P. ; DeKoven, Joel G. ; Silverberg, Jonathan I. ; Zug, Kathryn A. ; Marks, James ; Belsito, Donald V. ; Mathias, Toby ; Reeder, Margo J. ; Atwater, Amber R. ; Maibach, Howard I. ; Sasseville, Denis ; Zirwas, Matthew J. ; Fransway, Anthony F. ; Pratt, Melanie D. ; DeLeo, Vincent A. ; Fowler, Joseph F. ; Taylor, James S. / Occupationally Related Nickel Reactions : A Retrospective Analysis of the North American Contact Dermatitis Group Data 1998-2016. In: Dermatitis : contact, atopic, occupational, drug. 2019 ; Vol. 30, No. 5. pp. 306-313.
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abstract = "BACKGROUND: The epidemiology of nickel allergy in occupational settings is not well understood. OBJECTIVE: The aim of the study was to characterize occupationally related nickel allergy (ORNA). METHODS: This is a retrospective cross-sectional analysis of 44,378 patients patch tested by the North American Contact Dermatitis Group from 1998 to 2016. Characteristics of individuals with ORNA were compared with those with non-ORNA (NORNA). RESULTS: A total of 7928 (18.2{\%}) individuals were positive to nickel sulfate 2.5{\%}. Two hundred sixty-eight (3.4{\%}) had ORNA. As compared with NORNA, ORNA was statistically associated with the male sex (41.0{\%} vs 12.9{\%}, P < 0.001), a diagnosis of irritant contact dermatitis (22.4{\%} vs 12.0{\%}, P < 0.001), and no history of eczema (81.7{\%} vs 75.7{\%}, P = 0.0217). The most common sites of ORNA dermatitis were hand (39.9{\%}) and arm (18.1{\%}), which were significantly more common than in NORNA (P < 0.0001). Sixteen industry categories and 22 occupation categories were identified for ORNA; the most common industries were durable goods manufacturing (24.6{\%}) and personal services (15.7{\%}), and the most frequent occupations were hairdressers/cosmetologists/barbers (14.3{\%}), machine operators (9.3{\%}), and health care workers (7.1{\%}). Overall 30{\%} of ORNA occupations were in metalworking. Of 215 ORNA sources identified, instruments/phones/other equipment (16.3{\%}), vehicles/machinery (15.8{\%}), and tools (15.3{\%}) were the most common. CONCLUSIONS: Occupational nickel allergy is distinct from nonoccupational nickel allergy.",
author = "Warshaw, {Erin M.} and Schlarbaum, {Jamie P.} and DeKoven, {Joel G.} and Silverberg, {Jonathan I.} and Zug, {Kathryn A.} and James Marks and Belsito, {Donald V.} and Toby Mathias and Reeder, {Margo J.} and Atwater, {Amber R.} and Maibach, {Howard I.} and Denis Sasseville and Zirwas, {Matthew J.} and Fransway, {Anthony F.} and Pratt, {Melanie D.} and DeLeo, {Vincent A.} and Fowler, {Joseph F.} and Taylor, {James S.}",
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Warshaw, EM, Schlarbaum, JP, DeKoven, JG, Silverberg, JI, Zug, KA, Marks, J, Belsito, DV, Mathias, T, Reeder, MJ, Atwater, AR, Maibach, HI, Sasseville, D, Zirwas, MJ, Fransway, AF, Pratt, MD, DeLeo, VA, Fowler, JF & Taylor, JS 2019, 'Occupationally Related Nickel Reactions: A Retrospective Analysis of the North American Contact Dermatitis Group Data 1998-2016', Dermatitis : contact, atopic, occupational, drug, vol. 30, no. 5, pp. 306-313. https://doi.org/10.1097/DER.0000000000000516

Occupationally Related Nickel Reactions : A Retrospective Analysis of the North American Contact Dermatitis Group Data 1998-2016. / Warshaw, Erin M.; Schlarbaum, Jamie P.; DeKoven, Joel G.; Silverberg, Jonathan I.; Zug, Kathryn A.; Marks, James; Belsito, Donald V.; Mathias, Toby; Reeder, Margo J.; Atwater, Amber R.; Maibach, Howard I.; Sasseville, Denis; Zirwas, Matthew J.; Fransway, Anthony F.; Pratt, Melanie D.; DeLeo, Vincent A.; Fowler, Joseph F.; Taylor, James S.

In: Dermatitis : contact, atopic, occupational, drug, Vol. 30, No. 5, 01.09.2019, p. 306-313.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Occupationally Related Nickel Reactions

T2 - A Retrospective Analysis of the North American Contact Dermatitis Group Data 1998-2016

AU - Warshaw, Erin M.

AU - Schlarbaum, Jamie P.

AU - DeKoven, Joel G.

AU - Silverberg, Jonathan I.

AU - Zug, Kathryn A.

AU - Marks, James

AU - Belsito, Donald V.

AU - Mathias, Toby

AU - Reeder, Margo J.

AU - Atwater, Amber R.

AU - Maibach, Howard I.

AU - Sasseville, Denis

AU - Zirwas, Matthew J.

AU - Fransway, Anthony F.

AU - Pratt, Melanie D.

AU - DeLeo, Vincent A.

AU - Fowler, Joseph F.

AU - Taylor, James S.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - BACKGROUND: The epidemiology of nickel allergy in occupational settings is not well understood. OBJECTIVE: The aim of the study was to characterize occupationally related nickel allergy (ORNA). METHODS: This is a retrospective cross-sectional analysis of 44,378 patients patch tested by the North American Contact Dermatitis Group from 1998 to 2016. Characteristics of individuals with ORNA were compared with those with non-ORNA (NORNA). RESULTS: A total of 7928 (18.2%) individuals were positive to nickel sulfate 2.5%. Two hundred sixty-eight (3.4%) had ORNA. As compared with NORNA, ORNA was statistically associated with the male sex (41.0% vs 12.9%, P < 0.001), a diagnosis of irritant contact dermatitis (22.4% vs 12.0%, P < 0.001), and no history of eczema (81.7% vs 75.7%, P = 0.0217). The most common sites of ORNA dermatitis were hand (39.9%) and arm (18.1%), which were significantly more common than in NORNA (P < 0.0001). Sixteen industry categories and 22 occupation categories were identified for ORNA; the most common industries were durable goods manufacturing (24.6%) and personal services (15.7%), and the most frequent occupations were hairdressers/cosmetologists/barbers (14.3%), machine operators (9.3%), and health care workers (7.1%). Overall 30% of ORNA occupations were in metalworking. Of 215 ORNA sources identified, instruments/phones/other equipment (16.3%), vehicles/machinery (15.8%), and tools (15.3%) were the most common. CONCLUSIONS: Occupational nickel allergy is distinct from nonoccupational nickel allergy.

AB - BACKGROUND: The epidemiology of nickel allergy in occupational settings is not well understood. OBJECTIVE: The aim of the study was to characterize occupationally related nickel allergy (ORNA). METHODS: This is a retrospective cross-sectional analysis of 44,378 patients patch tested by the North American Contact Dermatitis Group from 1998 to 2016. Characteristics of individuals with ORNA were compared with those with non-ORNA (NORNA). RESULTS: A total of 7928 (18.2%) individuals were positive to nickel sulfate 2.5%. Two hundred sixty-eight (3.4%) had ORNA. As compared with NORNA, ORNA was statistically associated with the male sex (41.0% vs 12.9%, P < 0.001), a diagnosis of irritant contact dermatitis (22.4% vs 12.0%, P < 0.001), and no history of eczema (81.7% vs 75.7%, P = 0.0217). The most common sites of ORNA dermatitis were hand (39.9%) and arm (18.1%), which were significantly more common than in NORNA (P < 0.0001). Sixteen industry categories and 22 occupation categories were identified for ORNA; the most common industries were durable goods manufacturing (24.6%) and personal services (15.7%), and the most frequent occupations were hairdressers/cosmetologists/barbers (14.3%), machine operators (9.3%), and health care workers (7.1%). Overall 30% of ORNA occupations were in metalworking. Of 215 ORNA sources identified, instruments/phones/other equipment (16.3%), vehicles/machinery (15.8%), and tools (15.3%) were the most common. CONCLUSIONS: Occupational nickel allergy is distinct from nonoccupational nickel allergy.

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