Occurrence of Cranial Neoplasms in Pediatric Patients with Noonan Syndrome Receiving Growth Hormone: Is Screening with Brain MRI prior to Initiation of Growth Hormone Indicated?

Kanthi Bangalore Krishna, Pedro Pagan, Oscar Escobar, Jadranka Popovic

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Noonan syndrome (NS) is associated with short stature. Growth hormone treatment has been FDA approved for use in these patients. Children with NS are at a higher risk of developing benign and malignant proliferative disorders, primary brain tumors being one of them. Since growth hormone therapy can worsen the tumor burden, screening with a brain MRI prior to growth hormone initiation in NS patients is strongly recommended. Here we present two NS patients who developed different primary brain tumors while being on growth hormone therapy.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalHormone Research in Paediatrics
Volume88
Issue number6
DOIs
StatePublished - Dec 1 2017

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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