Occurrence of Cranial Neoplasms in Pediatric Patients with Noonan Syndrome Receiving Growth Hormone: Is Screening with Brain MRI prior to Initiation of Growth Hormone Indicated?

Kanthi Bangalore Krishna, Pedro Pagan, Oscar Escobar, Jadranka Popovic

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Noonan syndrome (NS) is associated with short stature. Growth hormone treatment has been FDA approved for use in these patients. Children with NS are at a higher risk of developing benign and malignant proliferative disorders, primary brain tumors being one of them. Since growth hormone therapy can worsen the tumor burden, screening with a brain MRI prior to growth hormone initiation in NS patients is strongly recommended. Here we present two NS patients who developed different primary brain tumors while being on growth hormone therapy.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalHormone Research in Paediatrics
Volume88
Issue number6
DOIs
StatePublished - Dec 1 2017

Fingerprint

Noonan Syndrome
Growth Hormone
Pediatrics
Brain
Brain Neoplasms
Neoplasms
Tumor Burden
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{dca41f2e72f947aa9acfe7c9c02c5dbd,
title = "Occurrence of Cranial Neoplasms in Pediatric Patients with Noonan Syndrome Receiving Growth Hormone: Is Screening with Brain MRI prior to Initiation of Growth Hormone Indicated?",
abstract = "Noonan syndrome (NS) is associated with short stature. Growth hormone treatment has been FDA approved for use in these patients. Children with NS are at a higher risk of developing benign and malignant proliferative disorders, primary brain tumors being one of them. Since growth hormone therapy can worsen the tumor burden, screening with a brain MRI prior to growth hormone initiation in NS patients is strongly recommended. Here we present two NS patients who developed different primary brain tumors while being on growth hormone therapy.",
author = "{Bangalore Krishna}, Kanthi and Pedro Pagan and Oscar Escobar and Jadranka Popovic",
year = "2017",
month = "12",
day = "1",
doi = "10.1159/000479107",
language = "English (US)",
volume = "88",
pages = "423--426",
journal = "Hormone Research in Paediatrics",
issn = "1663-2818",
publisher = "S. Karger AG",
number = "6",

}

TY - JOUR

T1 - Occurrence of Cranial Neoplasms in Pediatric Patients with Noonan Syndrome Receiving Growth Hormone

T2 - Is Screening with Brain MRI prior to Initiation of Growth Hormone Indicated?

AU - Bangalore Krishna, Kanthi

AU - Pagan, Pedro

AU - Escobar, Oscar

AU - Popovic, Jadranka

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Noonan syndrome (NS) is associated with short stature. Growth hormone treatment has been FDA approved for use in these patients. Children with NS are at a higher risk of developing benign and malignant proliferative disorders, primary brain tumors being one of them. Since growth hormone therapy can worsen the tumor burden, screening with a brain MRI prior to growth hormone initiation in NS patients is strongly recommended. Here we present two NS patients who developed different primary brain tumors while being on growth hormone therapy.

AB - Noonan syndrome (NS) is associated with short stature. Growth hormone treatment has been FDA approved for use in these patients. Children with NS are at a higher risk of developing benign and malignant proliferative disorders, primary brain tumors being one of them. Since growth hormone therapy can worsen the tumor burden, screening with a brain MRI prior to growth hormone initiation in NS patients is strongly recommended. Here we present two NS patients who developed different primary brain tumors while being on growth hormone therapy.

UR - http://www.scopus.com/inward/record.url?scp=85026468401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026468401&partnerID=8YFLogxK

U2 - 10.1159/000479107

DO - 10.1159/000479107

M3 - Article

C2 - 28746941

AN - SCOPUS:85026468401

VL - 88

SP - 423

EP - 426

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

SN - 1663-2818

IS - 6

ER -