Ocular surface epithelial atypia mimicking squamous neoplasia in association with ulcerative colitis

Sally S. Ong, Scott D. Walter, Xi Chen, Gargi Vora, Melissa Daluvoy, Alan D. Proia, Prithvi Mruthyunjaya

Research output: Contribution to journalArticle

Abstract

Purpose: Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC). Methods: Case report. Results: A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia. Shortly after treatment of the second eye, the patient was diagnosed with UC. Residual disease improved dramatically in response to systemic corticosteroids. Conclusions: Severe ocular surface epithelial atypia resembling OSSN may be seen in association with UC.

Original languageEnglish (US)
Pages (from-to)502-505
Number of pages4
JournalCornea
Volume36
Issue number4
DOIs
StatePublished - Apr 1 2017

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Ulcerative Colitis
Neoplasms
Optical Coherence Tomography
Inflammatory Bowel Diseases
Adrenal Cortex Hormones

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Ong, S. S., Walter, S. D., Chen, X., Vora, G., Daluvoy, M., Proia, A. D., & Mruthyunjaya, P. (2017). Ocular surface epithelial atypia mimicking squamous neoplasia in association with ulcerative colitis. Cornea, 36(4), 502-505. https://doi.org/10.1097/ICO.0000000000001144
Ong, Sally S. ; Walter, Scott D. ; Chen, Xi ; Vora, Gargi ; Daluvoy, Melissa ; Proia, Alan D. ; Mruthyunjaya, Prithvi. / Ocular surface epithelial atypia mimicking squamous neoplasia in association with ulcerative colitis. In: Cornea. 2017 ; Vol. 36, No. 4. pp. 502-505.
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abstract = "Purpose: Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC). Methods: Case report. Results: A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia. Shortly after treatment of the second eye, the patient was diagnosed with UC. Residual disease improved dramatically in response to systemic corticosteroids. Conclusions: Severe ocular surface epithelial atypia resembling OSSN may be seen in association with UC.",
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Ong, SS, Walter, SD, Chen, X, Vora, G, Daluvoy, M, Proia, AD & Mruthyunjaya, P 2017, 'Ocular surface epithelial atypia mimicking squamous neoplasia in association with ulcerative colitis', Cornea, vol. 36, no. 4, pp. 502-505. https://doi.org/10.1097/ICO.0000000000001144

Ocular surface epithelial atypia mimicking squamous neoplasia in association with ulcerative colitis. / Ong, Sally S.; Walter, Scott D.; Chen, Xi; Vora, Gargi; Daluvoy, Melissa; Proia, Alan D.; Mruthyunjaya, Prithvi.

In: Cornea, Vol. 36, No. 4, 01.04.2017, p. 502-505.

Research output: Contribution to journalArticle

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AU - Ong, Sally S.

AU - Walter, Scott D.

AU - Chen, Xi

AU - Vora, Gargi

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AU - Proia, Alan D.

AU - Mruthyunjaya, Prithvi

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AB - Purpose: Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC). Methods: Case report. Results: A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia. Shortly after treatment of the second eye, the patient was diagnosed with UC. Residual disease improved dramatically in response to systemic corticosteroids. Conclusions: Severe ocular surface epithelial atypia resembling OSSN may be seen in association with UC.

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