Oleic acid-derived oleoylethanolamide: A nutritional science perspective

Kate J. Bowen, Penny Margaret Kris-Etherton, Gregory C. Shearer, Sheila Grace West, Lavanya Reddivari, Peter J.H. Jones

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

The fatty acid ethanolamide oleoylethanolamide (OEA) is an endogenous lipid mediator derived from the monounsaturated fatty acid, oleic acid. OEA is synthesized from membrane glycerophospholipids and is a high-affinity agonist of the nuclear transcription factor peroxisome proliferator-activated receptor α (PPAR-α). Dietary intake of oleic acid elevates circulating levels of OEA in humans by increasing substrate availability for OEA biosynthesis. Numerous clinical studies demonstrate a beneficial relationship between high-oleic acid diets and body composition, with emerging evidence to suggest OEA may mediate this response through modulation of lipid metabolism and energy intake. OEA exposure has been shown to stimulate fatty acid uptake, lipolysis, and β-oxidation, and also promote food intake control. Future research on high-oleic acid diets and body composition is warranted to confirm these outcomes and elucidate the underlying mechanisms by which oleic acid exerts its biological effects. These findings have significant practical implications, as the oleic acid-derived OEA molecule may be a promising therapeutic agent for weight management and obesity treatment.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalProgress in Lipid Research
Volume67
DOIs
StatePublished - Jul 1 2017

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Nutritional Sciences
Oleic Acid
Nutrition
Body Composition
Fatty Acids
Glycerophospholipids
Diet
Monounsaturated Fatty Acids
Peroxisome Proliferator-Activated Receptors
Lipolysis
Biosynthesis
oleoylethanolamide
Energy Intake
Chemical analysis
Lipid Metabolism
Transcription Factors
Obesity
Eating
Modulation
Availability

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology

Cite this

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title = "Oleic acid-derived oleoylethanolamide: A nutritional science perspective",
abstract = "The fatty acid ethanolamide oleoylethanolamide (OEA) is an endogenous lipid mediator derived from the monounsaturated fatty acid, oleic acid. OEA is synthesized from membrane glycerophospholipids and is a high-affinity agonist of the nuclear transcription factor peroxisome proliferator-activated receptor α (PPAR-α). Dietary intake of oleic acid elevates circulating levels of OEA in humans by increasing substrate availability for OEA biosynthesis. Numerous clinical studies demonstrate a beneficial relationship between high-oleic acid diets and body composition, with emerging evidence to suggest OEA may mediate this response through modulation of lipid metabolism and energy intake. OEA exposure has been shown to stimulate fatty acid uptake, lipolysis, and β-oxidation, and also promote food intake control. Future research on high-oleic acid diets and body composition is warranted to confirm these outcomes and elucidate the underlying mechanisms by which oleic acid exerts its biological effects. These findings have significant practical implications, as the oleic acid-derived OEA molecule may be a promising therapeutic agent for weight management and obesity treatment.",
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Oleic acid-derived oleoylethanolamide : A nutritional science perspective. / Bowen, Kate J.; Kris-Etherton, Penny Margaret; Shearer, Gregory C.; West, Sheila Grace; Reddivari, Lavanya; Jones, Peter J.H.

In: Progress in Lipid Research, Vol. 67, 01.07.2017, p. 1-15.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Oleic acid-derived oleoylethanolamide

T2 - A nutritional science perspective

AU - Bowen, Kate J.

AU - Kris-Etherton, Penny Margaret

AU - Shearer, Gregory C.

AU - West, Sheila Grace

AU - Reddivari, Lavanya

AU - Jones, Peter J.H.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - The fatty acid ethanolamide oleoylethanolamide (OEA) is an endogenous lipid mediator derived from the monounsaturated fatty acid, oleic acid. OEA is synthesized from membrane glycerophospholipids and is a high-affinity agonist of the nuclear transcription factor peroxisome proliferator-activated receptor α (PPAR-α). Dietary intake of oleic acid elevates circulating levels of OEA in humans by increasing substrate availability for OEA biosynthesis. Numerous clinical studies demonstrate a beneficial relationship between high-oleic acid diets and body composition, with emerging evidence to suggest OEA may mediate this response through modulation of lipid metabolism and energy intake. OEA exposure has been shown to stimulate fatty acid uptake, lipolysis, and β-oxidation, and also promote food intake control. Future research on high-oleic acid diets and body composition is warranted to confirm these outcomes and elucidate the underlying mechanisms by which oleic acid exerts its biological effects. These findings have significant practical implications, as the oleic acid-derived OEA molecule may be a promising therapeutic agent for weight management and obesity treatment.

AB - The fatty acid ethanolamide oleoylethanolamide (OEA) is an endogenous lipid mediator derived from the monounsaturated fatty acid, oleic acid. OEA is synthesized from membrane glycerophospholipids and is a high-affinity agonist of the nuclear transcription factor peroxisome proliferator-activated receptor α (PPAR-α). Dietary intake of oleic acid elevates circulating levels of OEA in humans by increasing substrate availability for OEA biosynthesis. Numerous clinical studies demonstrate a beneficial relationship between high-oleic acid diets and body composition, with emerging evidence to suggest OEA may mediate this response through modulation of lipid metabolism and energy intake. OEA exposure has been shown to stimulate fatty acid uptake, lipolysis, and β-oxidation, and also promote food intake control. Future research on high-oleic acid diets and body composition is warranted to confirm these outcomes and elucidate the underlying mechanisms by which oleic acid exerts its biological effects. These findings have significant practical implications, as the oleic acid-derived OEA molecule may be a promising therapeutic agent for weight management and obesity treatment.

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