Olfaction and incident Parkinson disease in US white and black older adults

Honglei Chen, Srishti Shrestha, Xuemei Huang, Samay Jain, Xuguang Guo, Gregory J. Tranah, Melissa E. Garcia, Suzanne Satterfield, Caroline Phillips, Tamara B. Harris

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To investigate olfaction in relation to incident Parkinson disease (PD) in US white and black older adults. Methods: The study included 1,510 white (mean age 75.6 years) and 952 black (75.4 years) participants of the Health, Aging, and Body Composition study. We evaluated the olfaction of study participants with the Brief Smell Identification Test (BSIT) in 1999-2000. We retrospectively adjudicated PD cases identified through August 31, 2012, using multiple data sources. We used multivariable Cox models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During an average of 9.8 years of follow-up, we identified a total of 42 incident PD cases, including 30 white and 12 black participants. Overall, poor sense of smell, as indicated by a lower BSIT score, was associated with higher risk of PD. Compared with the highest tertile of BSIT (t3), the HR was 1.3 (95% CI 0.5-3.6) for the second tertile (t2) and 4.8 (95% CI 2.0-11.2) for the lowest tertile (t1) (p trend < 0.00001). Further analyses revealed significant associations for incident PD in both the first 5 years of follow-up (HR t1/[t2+t3] 4.2, 95% CI 1.7-10.8) and thereafter (HR t1/[t2+t3] 4.1, 95% CI 1.7-9.8). This association appeared to be stronger in white (HR t1/[t2+t3] 4.9, 95% CI 2.3-10.5) than in black participants (HR t1/[t2+t3] 2.5, 95% CI 0.8-8.1), and in men (HR t1/[t2+t3] 5.4, 95% CI 2.3-12.9) than in women (HR t1/[t2+t3] 2.9, 95% CI 1.1-7.8). Conclusions: Poor olfaction predicts PD in short and intermediate terms; the possibility of stronger associations among men and white participants warrants further investigation.

Original languageEnglish (US)
Pages (from-to)1441-1447
Number of pages7
JournalNeurology
Volume89
Issue number14
DOIs
StatePublished - Oct 3 2017

Fingerprint

Smell
Parkinson Disease
Confidence Intervals
hydroquinone
Information Storage and Retrieval
Body Composition
Proportional Hazards Models
Health

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Chen, H., Shrestha, S., Huang, X., Jain, S., Guo, X., Tranah, G. J., ... Harris, T. B. (2017). Olfaction and incident Parkinson disease in US white and black older adults. Neurology, 89(14), 1441-1447. https://doi.org/10.1212/WNL.0000000000004382
Chen, Honglei ; Shrestha, Srishti ; Huang, Xuemei ; Jain, Samay ; Guo, Xuguang ; Tranah, Gregory J. ; Garcia, Melissa E. ; Satterfield, Suzanne ; Phillips, Caroline ; Harris, Tamara B. / Olfaction and incident Parkinson disease in US white and black older adults. In: Neurology. 2017 ; Vol. 89, No. 14. pp. 1441-1447.
@article{513fe0462eb54148993320b10cff067b,
title = "Olfaction and incident Parkinson disease in US white and black older adults",
abstract = "Objective: To investigate olfaction in relation to incident Parkinson disease (PD) in US white and black older adults. Methods: The study included 1,510 white (mean age 75.6 years) and 952 black (75.4 years) participants of the Health, Aging, and Body Composition study. We evaluated the olfaction of study participants with the Brief Smell Identification Test (BSIT) in 1999-2000. We retrospectively adjudicated PD cases identified through August 31, 2012, using multiple data sources. We used multivariable Cox models to estimate hazard ratios (HRs) and 95{\%} confidence intervals (CIs). Results: During an average of 9.8 years of follow-up, we identified a total of 42 incident PD cases, including 30 white and 12 black participants. Overall, poor sense of smell, as indicated by a lower BSIT score, was associated with higher risk of PD. Compared with the highest tertile of BSIT (t3), the HR was 1.3 (95{\%} CI 0.5-3.6) for the second tertile (t2) and 4.8 (95{\%} CI 2.0-11.2) for the lowest tertile (t1) (p trend < 0.00001). Further analyses revealed significant associations for incident PD in both the first 5 years of follow-up (HR t1/[t2+t3] 4.2, 95{\%} CI 1.7-10.8) and thereafter (HR t1/[t2+t3] 4.1, 95{\%} CI 1.7-9.8). This association appeared to be stronger in white (HR t1/[t2+t3] 4.9, 95{\%} CI 2.3-10.5) than in black participants (HR t1/[t2+t3] 2.5, 95{\%} CI 0.8-8.1), and in men (HR t1/[t2+t3] 5.4, 95{\%} CI 2.3-12.9) than in women (HR t1/[t2+t3] 2.9, 95{\%} CI 1.1-7.8). Conclusions: Poor olfaction predicts PD in short and intermediate terms; the possibility of stronger associations among men and white participants warrants further investigation.",
author = "Honglei Chen and Srishti Shrestha and Xuemei Huang and Samay Jain and Xuguang Guo and Tranah, {Gregory J.} and Garcia, {Melissa E.} and Suzanne Satterfield and Caroline Phillips and Harris, {Tamara B.}",
year = "2017",
month = "10",
day = "3",
doi = "10.1212/WNL.0000000000004382",
language = "English (US)",
volume = "89",
pages = "1441--1447",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "14",

}

Chen, H, Shrestha, S, Huang, X, Jain, S, Guo, X, Tranah, GJ, Garcia, ME, Satterfield, S, Phillips, C & Harris, TB 2017, 'Olfaction and incident Parkinson disease in US white and black older adults', Neurology, vol. 89, no. 14, pp. 1441-1447. https://doi.org/10.1212/WNL.0000000000004382

Olfaction and incident Parkinson disease in US white and black older adults. / Chen, Honglei; Shrestha, Srishti; Huang, Xuemei; Jain, Samay; Guo, Xuguang; Tranah, Gregory J.; Garcia, Melissa E.; Satterfield, Suzanne; Phillips, Caroline; Harris, Tamara B.

In: Neurology, Vol. 89, No. 14, 03.10.2017, p. 1441-1447.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Olfaction and incident Parkinson disease in US white and black older adults

AU - Chen, Honglei

AU - Shrestha, Srishti

AU - Huang, Xuemei

AU - Jain, Samay

AU - Guo, Xuguang

AU - Tranah, Gregory J.

AU - Garcia, Melissa E.

AU - Satterfield, Suzanne

AU - Phillips, Caroline

AU - Harris, Tamara B.

PY - 2017/10/3

Y1 - 2017/10/3

N2 - Objective: To investigate olfaction in relation to incident Parkinson disease (PD) in US white and black older adults. Methods: The study included 1,510 white (mean age 75.6 years) and 952 black (75.4 years) participants of the Health, Aging, and Body Composition study. We evaluated the olfaction of study participants with the Brief Smell Identification Test (BSIT) in 1999-2000. We retrospectively adjudicated PD cases identified through August 31, 2012, using multiple data sources. We used multivariable Cox models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During an average of 9.8 years of follow-up, we identified a total of 42 incident PD cases, including 30 white and 12 black participants. Overall, poor sense of smell, as indicated by a lower BSIT score, was associated with higher risk of PD. Compared with the highest tertile of BSIT (t3), the HR was 1.3 (95% CI 0.5-3.6) for the second tertile (t2) and 4.8 (95% CI 2.0-11.2) for the lowest tertile (t1) (p trend < 0.00001). Further analyses revealed significant associations for incident PD in both the first 5 years of follow-up (HR t1/[t2+t3] 4.2, 95% CI 1.7-10.8) and thereafter (HR t1/[t2+t3] 4.1, 95% CI 1.7-9.8). This association appeared to be stronger in white (HR t1/[t2+t3] 4.9, 95% CI 2.3-10.5) than in black participants (HR t1/[t2+t3] 2.5, 95% CI 0.8-8.1), and in men (HR t1/[t2+t3] 5.4, 95% CI 2.3-12.9) than in women (HR t1/[t2+t3] 2.9, 95% CI 1.1-7.8). Conclusions: Poor olfaction predicts PD in short and intermediate terms; the possibility of stronger associations among men and white participants warrants further investigation.

AB - Objective: To investigate olfaction in relation to incident Parkinson disease (PD) in US white and black older adults. Methods: The study included 1,510 white (mean age 75.6 years) and 952 black (75.4 years) participants of the Health, Aging, and Body Composition study. We evaluated the olfaction of study participants with the Brief Smell Identification Test (BSIT) in 1999-2000. We retrospectively adjudicated PD cases identified through August 31, 2012, using multiple data sources. We used multivariable Cox models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During an average of 9.8 years of follow-up, we identified a total of 42 incident PD cases, including 30 white and 12 black participants. Overall, poor sense of smell, as indicated by a lower BSIT score, was associated with higher risk of PD. Compared with the highest tertile of BSIT (t3), the HR was 1.3 (95% CI 0.5-3.6) for the second tertile (t2) and 4.8 (95% CI 2.0-11.2) for the lowest tertile (t1) (p trend < 0.00001). Further analyses revealed significant associations for incident PD in both the first 5 years of follow-up (HR t1/[t2+t3] 4.2, 95% CI 1.7-10.8) and thereafter (HR t1/[t2+t3] 4.1, 95% CI 1.7-9.8). This association appeared to be stronger in white (HR t1/[t2+t3] 4.9, 95% CI 2.3-10.5) than in black participants (HR t1/[t2+t3] 2.5, 95% CI 0.8-8.1), and in men (HR t1/[t2+t3] 5.4, 95% CI 2.3-12.9) than in women (HR t1/[t2+t3] 2.9, 95% CI 1.1-7.8). Conclusions: Poor olfaction predicts PD in short and intermediate terms; the possibility of stronger associations among men and white participants warrants further investigation.

UR - http://www.scopus.com/inward/record.url?scp=85030765734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030765734&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000004382

DO - 10.1212/WNL.0000000000004382

M3 - Article

C2 - 28878051

AN - SCOPUS:85030765734

VL - 89

SP - 1441

EP - 1447

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 14

ER -