Oligosachharide modified biomimetic surfactant polymer for non-thrombogenic interface applications: Platelet Adhesion Studies

Anirban Sen Gupta; Emily Link; Shuwu Wang; Kandice Kottke-Marchant; Roger E. Marchant

Oligosachharide modified biomimetic surfactant polymer for non-thrombogenic interface applications: Platelet Adhesion Studies

Anirban Sen Gupta, Emily Link, Shuwu Wang, Kandice Kottke-Marchant, Roger E. Marchant

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Platelet adhesion of oligosachharide modified biomimetic surfactant polymer for non-thrombogenic interface applications was investigated. Low-molecular weight poly(vinyl amine) (PVAm) with well-defined structure and narrow polydispersity was synthesized from poly(N-vinylformamide). Blood was drawn from healthy, aspirin-refraining adult donors into 3.8% sodium citrate anticoagulant in a 9:1 ratio. The number of adhered platelets per mm ² was found to be significantly lower for surfactant-coated disks compared with uncoated disks in both platelet rich plasma (PRP) and human whole blood (WB).

Original language	English (US)
Title of host publication	2004 AIChE Annual Meeting, Conference Proceedings
Pages	6377-6379
Number of pages	3
State	Published - 2004
Event	2004 AIChE Annual Meeting - Austin, TX, United States Duration: Nov 7 2004 → Nov 12 2004

Other

Other	2004 AIChE Annual Meeting
Country	United States
City	Austin, TX
Period	11/7/04 → 11/12/04

All Science Journal Classification (ASJC) codes

Engineering(all)

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title = "Oligosachharide modified biomimetic surfactant polymer for non-thrombogenic interface applications: Platelet Adhesion Studies",

abstract = "Platelet adhesion of oligosachharide modified biomimetic surfactant polymer for non-thrombogenic interface applications was investigated. Low-molecular weight poly(vinyl amine) (PVAm) with well-defined structure and narrow polydispersity was synthesized from poly(N-vinylformamide). Blood was drawn from healthy, aspirin-refraining adult donors into 3.8% sodium citrate anticoagulant in a 9:1 ratio. The number of adhered platelets per mm 2 was found to be significantly lower for surfactant-coated disks compared with uncoated disks in both platelet rich plasma (PRP) and human whole blood (WB).",

author = "Gupta, {Anirban Sen} and Emily Link and Shuwu Wang and Kandice Kottke-Marchant and Marchant, {Roger E.}",

year = "2004",

language = "English (US)",

pages = "6377--6379",

booktitle = "2004 AIChE Annual Meeting, Conference Proceedings",

note = "2004 AIChE Annual Meeting ; Conference date: 07-11-2004 Through 12-11-2004",

}

Oligosachharide modified biomimetic surfactant polymer for non-thrombogenic interface applications : Platelet Adhesion Studies. / Gupta, Anirban Sen; Link, Emily; Wang, Shuwu; Kottke-Marchant, Kandice; Marchant, Roger E.

2004 AIChE Annual Meeting, Conference Proceedings. 2004. p. 6377-6379 90d.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Oligosachharide modified biomimetic surfactant polymer for non-thrombogenic interface applications

T2 - 2004 AIChE Annual Meeting

AU - Gupta, Anirban Sen

AU - Link, Emily

AU - Wang, Shuwu

AU - Kottke-Marchant, Kandice

AU - Marchant, Roger E.

PY - 2004

Y1 - 2004

N2 - Platelet adhesion of oligosachharide modified biomimetic surfactant polymer for non-thrombogenic interface applications was investigated. Low-molecular weight poly(vinyl amine) (PVAm) with well-defined structure and narrow polydispersity was synthesized from poly(N-vinylformamide). Blood was drawn from healthy, aspirin-refraining adult donors into 3.8% sodium citrate anticoagulant in a 9:1 ratio. The number of adhered platelets per mm 2 was found to be significantly lower for surfactant-coated disks compared with uncoated disks in both platelet rich plasma (PRP) and human whole blood (WB).

AB - Platelet adhesion of oligosachharide modified biomimetic surfactant polymer for non-thrombogenic interface applications was investigated. Low-molecular weight poly(vinyl amine) (PVAm) with well-defined structure and narrow polydispersity was synthesized from poly(N-vinylformamide). Blood was drawn from healthy, aspirin-refraining adult donors into 3.8% sodium citrate anticoagulant in a 9:1 ratio. The number of adhered platelets per mm 2 was found to be significantly lower for surfactant-coated disks compared with uncoated disks in both platelet rich plasma (PRP) and human whole blood (WB).

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BT - 2004 AIChE Annual Meeting, Conference Proceedings

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