Omega-3 polyunsaturated fatty acids and health

Michelle A. Briggs, Kate J. Bowen, Penny M. Kris-Etherton

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There is mounting evidence that long-chain omega 3 (n-3) polyunsaturated fatty acids (PUFAs) have many health benets. These long-chain n-3 PUFAs include alpha-linolenic acid (ALA; 18:3n-3 or 18:3 Δ9,12,15), eicosapentaenoic acid (EPA; 20:5n-3 or 20:5 Δ5,8,11,14,17), docosapentaenoic acid (DPA; 22:5n-3 or 22:5 Δ7,10,13,16,19), and docosahexaenoic acid (DHA; 22:6n-3 or 22:6 Δ4,7,10,13,16,19). Their health benets appear to be associated with several different aspects, including their structure, their interactions with proteins that alter gene expression, and their unique metabolic fates. Structurally, when long-chain n-3 PUFAs are incorporated into cell membranes, they increase membrane uidity, thereby inuencing cell function. For example, higher n-3 PUFA content in neuronal membranes has been shown to improve neuron function [1]. Besides affecting membrane uidity, these fatty acids can also inuence the structure and function of proteins embedded in the phospholipid bilayer [2]. As mediators of cell sensors and receptors (e.g., G protein-coupled receptor 120 [3]), long-chain n-3 PUFAs also have a major impact on gene expression [4]. But perhaps the most studied aspect of long-chain n-3 PUFA relates to their metabolic fates. These fatty acids enter biochemical pathways that produce anti-inammatory compounds (Figure 23.1); in turn, these anti-inammatory agents decrease the risk of chronic diseases [5].

Original languageEnglish (US)
Title of host publicationFood Lipids
Subtitle of host publicationChemistry, Nutrition, and Biotechnology, Fourth Edition
PublisherCRC Press
Pages603-625
Number of pages23
ISBN (Electronic)9781498744874
ISBN (Print)9781498744850
DOIs
StatePublished - Jan 1 2017

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Polyunsaturated fatty acids
Omega-3 Fatty Acids
Unsaturated Fatty Acids
omega-3 fatty acids
polyunsaturated fatty acids
Health
Acids
Proteins
Membranes
Fatty acids
Gene expression
Fatty Acids
docosapentaenoic acid
fatty acids
Gene Expression
gene expression
alpha-Linolenic Acid
Eicosapentaenoic Acid
Docosahexaenoic Acids
Phospholipids

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)

Cite this

Briggs, M. A., Bowen, K. J., & Kris-Etherton, P. M. (2017). Omega-3 polyunsaturated fatty acids and health. In Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition (pp. 603-625). CRC Press. https://doi.org/10.1201/9781315151854
Briggs, Michelle A. ; Bowen, Kate J. ; Kris-Etherton, Penny M. / Omega-3 polyunsaturated fatty acids and health. Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition. CRC Press, 2017. pp. 603-625
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Briggs, MA, Bowen, KJ & Kris-Etherton, PM 2017, Omega-3 polyunsaturated fatty acids and health. in Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition. CRC Press, pp. 603-625. https://doi.org/10.1201/9781315151854

Omega-3 polyunsaturated fatty acids and health. / Briggs, Michelle A.; Bowen, Kate J.; Kris-Etherton, Penny M.

Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition. CRC Press, 2017. p. 603-625.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Briggs MA, Bowen KJ, Kris-Etherton PM. Omega-3 polyunsaturated fatty acids and health. In Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition. CRC Press. 2017. p. 603-625 https://doi.org/10.1201/9781315151854