On a FOX hunt: Functions of FOX transcriptional regulators in bladder cancer

Hironobu Yamashita, Vasty Osei Amponsa, Joshua Warrick, Zongyu Zheng, Peter E. Clark, Jay Raman, Xue Ru Wu, Cathy Mendelsohn, David Degraff

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Genomic and transcriptional studies have identified discrete molecular subtypes of bladder cancer. These observations could be the starting point to identify new treatments. Several members of the forkhead box (FOX) superfamily of transcription factors have been found to be differentially expressed in the different bladder cancer subtypes. In addition, the FOXA protein family are key regulators of embryonic bladder development and patterning. Both experimental and clinical data support a role for FOXA1 and FOXA2 in urothelial carcinoma. FOXA1 is expressed in embryonic and adult urothelium and its expression is altered in urothelial carcinomas and across disparate molecular bladder cancer subtypes. FOXA2 is normally absent from the adult urothelium, but developmental studies identified FOXA2 as a marker of a transient urothelial progenitor cell population during bladder development. Studies also implicate FOXA2 in bladder cancer and several other FOX proteins might be involved in development and/or progression of this disease; for example, FOXA1 and FOXO3A have been associated with clinical patient outcomes. Future studies should investigate to what extent and by which mechanisms FOX proteins might be directly involved in bladder cancer pathogenesis and treatment responses.

Original languageEnglish (US)
Pages (from-to)98-106
Number of pages9
JournalNature Reviews Urology
Volume14
Issue number2
DOIs
StatePublished - Feb 1 2017

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Urinary Bladder Neoplasms
Forkhead Transcription Factors
Urothelium
Urinary Bladder
Carcinoma
Embryonic Development
Disease Progression
Stem Cells
Therapeutics
Population
Proteins

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Yamashita, Hironobu ; Amponsa, Vasty Osei ; Warrick, Joshua ; Zheng, Zongyu ; Clark, Peter E. ; Raman, Jay ; Wu, Xue Ru ; Mendelsohn, Cathy ; Degraff, David. / On a FOX hunt : Functions of FOX transcriptional regulators in bladder cancer. In: Nature Reviews Urology. 2017 ; Vol. 14, No. 2. pp. 98-106.
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On a FOX hunt : Functions of FOX transcriptional regulators in bladder cancer. / Yamashita, Hironobu; Amponsa, Vasty Osei; Warrick, Joshua; Zheng, Zongyu; Clark, Peter E.; Raman, Jay; Wu, Xue Ru; Mendelsohn, Cathy; Degraff, David.

In: Nature Reviews Urology, Vol. 14, No. 2, 01.02.2017, p. 98-106.

Research output: Contribution to journalReview article

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AU - Yamashita, Hironobu

AU - Amponsa, Vasty Osei

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AU - Clark, Peter E.

AU - Raman, Jay

AU - Wu, Xue Ru

AU - Mendelsohn, Cathy

AU - Degraff, David

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