On demand one-step generation of functional polymeric microparticles in droplet microfluidics

Xu Yu, Gong Cheng, Ming Da Zhou, Siyang Zheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports one-step synthesis of monodisperse functional poly(D, L-lactic-co-glycolic acid) (PLGA) microspheres by generation of reversed microemulsion droplets in aqueous phase inside microfluidic chips and controlled evaporation of the organic solvent. By controlling the flow rate of the microemulsion phase, functional PLGA polymeric microspheres with narrow size distribution and diameters in the range of ∼50-100 μm were obtained. As a demonstration of the versatility of the approach, fluorescent PLGA@QDs, magnetic PLGA@Fe3O4 and PLGA@CNTs polymeric microspheres were successfully generated by encapsulating the fluorescent CdTe: Zn2+ quantum dots (QDs), superparamagnetic Fe3O4 nanoparticles and water-soluble carbon nanotubes (CNTs), respectively.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages1235-1237
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

Fingerprint

Microspheres
Microfluidics
Microemulsions
Semiconductor quantum dots
Carbon nanotubes
Organic solvents
Evaporation
Demonstrations
Flow rate
Nanoparticles
Acids
Water

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Yu, X., Cheng, G., Zhou, M. D., & Zheng, S. (2014). On demand one-step generation of functional polymeric microparticles in droplet microfluidics. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 1235-1237). Chemical and Biological Microsystems Society.
Yu, Xu ; Cheng, Gong ; Zhou, Ming Da ; Zheng, Siyang. / On demand one-step generation of functional polymeric microparticles in droplet microfluidics. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 1235-1237
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title = "On demand one-step generation of functional polymeric microparticles in droplet microfluidics",
abstract = "This paper reports one-step synthesis of monodisperse functional poly(D, L-lactic-co-glycolic acid) (PLGA) microspheres by generation of reversed microemulsion droplets in aqueous phase inside microfluidic chips and controlled evaporation of the organic solvent. By controlling the flow rate of the microemulsion phase, functional PLGA polymeric microspheres with narrow size distribution and diameters in the range of ∼50-100 μm were obtained. As a demonstration of the versatility of the approach, fluorescent PLGA@QDs, magnetic PLGA@Fe3O4 and PLGA@CNTs polymeric microspheres were successfully generated by encapsulating the fluorescent CdTe: Zn2+ quantum dots (QDs), superparamagnetic Fe3O4 nanoparticles and water-soluble carbon nanotubes (CNTs), respectively.",
author = "Xu Yu and Gong Cheng and Zhou, {Ming Da} and Siyang Zheng",
year = "2014",
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Yu, X, Cheng, G, Zhou, MD & Zheng, S 2014, On demand one-step generation of functional polymeric microparticles in droplet microfluidics. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, pp. 1235-1237, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 10/26/14.

On demand one-step generation of functional polymeric microparticles in droplet microfluidics. / Yu, Xu; Cheng, Gong; Zhou, Ming Da; Zheng, Siyang.

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 1235-1237.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - On demand one-step generation of functional polymeric microparticles in droplet microfluidics

AU - Yu, Xu

AU - Cheng, Gong

AU - Zhou, Ming Da

AU - Zheng, Siyang

PY - 2014

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N2 - This paper reports one-step synthesis of monodisperse functional poly(D, L-lactic-co-glycolic acid) (PLGA) microspheres by generation of reversed microemulsion droplets in aqueous phase inside microfluidic chips and controlled evaporation of the organic solvent. By controlling the flow rate of the microemulsion phase, functional PLGA polymeric microspheres with narrow size distribution and diameters in the range of ∼50-100 μm were obtained. As a demonstration of the versatility of the approach, fluorescent PLGA@QDs, magnetic PLGA@Fe3O4 and PLGA@CNTs polymeric microspheres were successfully generated by encapsulating the fluorescent CdTe: Zn2+ quantum dots (QDs), superparamagnetic Fe3O4 nanoparticles and water-soluble carbon nanotubes (CNTs), respectively.

AB - This paper reports one-step synthesis of monodisperse functional poly(D, L-lactic-co-glycolic acid) (PLGA) microspheres by generation of reversed microemulsion droplets in aqueous phase inside microfluidic chips and controlled evaporation of the organic solvent. By controlling the flow rate of the microemulsion phase, functional PLGA polymeric microspheres with narrow size distribution and diameters in the range of ∼50-100 μm were obtained. As a demonstration of the versatility of the approach, fluorescent PLGA@QDs, magnetic PLGA@Fe3O4 and PLGA@CNTs polymeric microspheres were successfully generated by encapsulating the fluorescent CdTe: Zn2+ quantum dots (QDs), superparamagnetic Fe3O4 nanoparticles and water-soluble carbon nanotubes (CNTs), respectively.

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Yu X, Cheng G, Zhou MD, Zheng S. On demand one-step generation of functional polymeric microparticles in droplet microfluidics. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society. 2014. p. 1235-1237