On-demand one-step synthesis of monodisperse functional polymeric microspheres with droplet microfluidics

Xu Yu, Gong Cheng, Ming Da Zhou, Si Yang Zheng

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A simple and robust method for one-step synthesis of monodisperse functional polymeric microspheres was established by generation of reversed microemulsion droplets in aqueous phase inside microfluidic chips and controlled evaporation of the organic solvent. Using this method, water-soluble nanomaterials can be easily encapsulated into biodegradable Poly(d,l-lactic-co-glycolic acid) (PLGA) to form functional microspheres. By controlling the flow rate of microemulsion phase, PLGA polymeric microspheres with narrow size distribution and diameters in the range of ∼50-100 μm were obtained. As a demonstration of the versatility of the approach, high-quality fluorescent CdTe:Zn2+ quantum dots (QDs) of various emission spectra, superparamagnetic Fe3O4 nanoparticles, and water-soluble carbon nanotubes (CNTs) were used to synthesize fluorescent PLGA@QDs, magnetic PLGA@Fe3O4, and PLGA@CNTs polymeric microspheres, respectively. In order to show specific applications, the PLGA@Fe3O4 were modified with polydopamine (PDA), and then the silver nanoparticles grew on the surfaces of the PLGA@Fe3O4@PDA polymeric microspheres by reducting the Ag+ to Ag0. The as-prepared PLGA@Fe3O4@PDA-Ag microspheres showed a highly efficient catalytic reduction of the 4-nitrophenol, a highly toxic substance. The monodisperse uniform functional PLGA polymeric microspheres can potentially be critically important for multiple biomedical applications.

Original languageEnglish (US)
Pages (from-to)3982-3992
Number of pages11
JournalLangmuir
Volume31
Issue number13
DOIs
StatePublished - Mar 18 2015

Fingerprint

Microspheres
Microfluidics
carbon nanotubes
quantum dots
nanoparticles
versatility
synthesis
water
emission spectra
flow velocity
chips
silver
evaporation
Microemulsions
acids
Carbon Nanotubes
glycolic acid
Semiconductor quantum dots
Carbon nanotubes
Nanoparticles

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Yu, Xu ; Cheng, Gong ; Zhou, Ming Da ; Zheng, Si Yang. / On-demand one-step synthesis of monodisperse functional polymeric microspheres with droplet microfluidics. In: Langmuir. 2015 ; Vol. 31, No. 13. pp. 3982-3992.
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On-demand one-step synthesis of monodisperse functional polymeric microspheres with droplet microfluidics. / Yu, Xu; Cheng, Gong; Zhou, Ming Da; Zheng, Si Yang.

In: Langmuir, Vol. 31, No. 13, 18.03.2015, p. 3982-3992.

Research output: Contribution to journalArticle

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