On the mechanism of fructose 1,6-diphosphatase: Inhibition by methyl d-fructoside 1,6-diphosphate

S. J. Benkovic, M. M. de Maine, J. J. Kleinschuster

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

From a comparison of the effects of potential inhibitors it is concluded that the furanose configuration of fructose 1,6-diphosphate is utilized by FDPase. The partial competitive inhibitor methyl d-fructoside 1,6-diphosphate, apparently induces a conformational change that permits acetylation of the active site. The probable importance of the C-2 hydroxyl of the sugar phosphate in the mechanism of FDPase is discussed.

Original languageEnglish (US)
Pages (from-to)248-251
Number of pages4
JournalArchives of Biochemistry and Biophysics
Volume139
Issue number1
DOIs
StatePublished - Jul 1970

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology

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