On the Mechanism of Platelet Function Inhibition by Acetylsalicylic Acid

Hamid Al-Mondhiry, A. J. Marcus, T. H. Spaet

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Aspirin produces alteration of platelet function characterized by loss of secondary aggregation in response to ADP or epinephrine, and inhibition of aggregation by collagen. In addition, platelet factor 3 release by these reagents is reduced. A similar platelet lesion was produced by an acetylating agent, acetic anhydride, supporting earlier concepts that aspirin activity against platelets may be a consequence of acetylation. An attempt to identify specific acetylation of platelets with acetyl-1-14C salicylic acid was unsuccessful. Although platelet uptake of the label was demonstrated, metabolic incorporation of acetate could not be excluded.

Original languageEnglish (US)
Pages (from-to)632-636
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume133
Issue number2
DOIs
StatePublished - Jan 1 1970

Fingerprint

Platelets
Aspirin
Blood Platelets
Acetylation
Agglomeration
Platelet Factor 3
Salicylic Acid
Adenosine Diphosphate
Epinephrine
Labels
Acetates
Collagen

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Al-Mondhiry, Hamid ; Marcus, A. J. ; Spaet, T. H. / On the Mechanism of Platelet Function Inhibition by Acetylsalicylic Acid. In: Proceedings of the Society for Experimental Biology and Medicine. 1970 ; Vol. 133, No. 2. pp. 632-636.
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On the Mechanism of Platelet Function Inhibition by Acetylsalicylic Acid. / Al-Mondhiry, Hamid; Marcus, A. J.; Spaet, T. H.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 133, No. 2, 01.01.1970, p. 632-636.

Research output: Contribution to journalArticle

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