On the Mechanism of Platelet Function Inhibition by Acetylsalicylic Acid

H. Mondhiry, A. J. Marcus, T. H. Spaet

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Aspirin produces alteration of platelet function characterized by loss of secondary aggregation in response to ADP or epinephrine, and inhibition of aggregation by collagen. In addition, platelet factor 3 release by these reagents is reduced. A similar platelet lesion was produced by an acetylating agent, acetic anhydride, supporting earlier concepts that aspirin activity against platelets may be a consequence of acetylation. An attempt to identify specific acetylation of platelets with acetyl-1-14C salicylic acid was unsuccessful. Although platelet uptake of the label was demonstrated, metabolic incorporation of acetate could not be excluded.

Original languageEnglish (US)
Pages (from-to)632-636
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume133
Issue number2
DOIs
StatePublished - Feb 1970

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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