Once is too much: Conditioned aversion develops immediately and predicts future cocaine self-administration behavior in rats

Elizabeth M. Colechio, Caesar G. Imperio, Patricia S. Grigson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Rats emit aversive taste reactivity (TR) behavior (i.e., gapes) following intraoral delivery of a cocainepaired taste cue and greater conditioned aversive TR at the end of training predicts greater drug-seeking and taking. Here, we examined the development of this conditioned aversive TR behavior on a trial-by-trial basis in an effort to determine when the change in behavior occurs and whether early changes in this behavior can be used to predict later drug taking. The results show that conditioned aversive TR to a cocaine-paired cue occurs very early in training (i.e., following as few as 1-2 taste-drug pairings) and, importantly, that it can be used to predict later drug seeking and drug taking in rats.

Original languageEnglish (US)
Pages (from-to)207-216
Number of pages10
JournalBehavioral Neuroscience
Volume128
Issue number2
DOIs
StatePublished - Apr 1 2014

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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