Oncogenic beta-catenin signaling networks in colorectal cancer.

Serge Y. Fuchs, Andrei V. Ougolkov, Vladimir Spiegelman, Toshinari Minamoto

Research output: Contribution to journalReview article

97 Citations (Scopus)

Abstract

Beta-catenin has two distinct functions, namely, maintaining cell-to-cell adhesion and mediating the Wnt/beta-catenin signal transduction pathway, which plays pivotal roles in embryogenesis and in malignant transformation of cells. The oncogenic properties of Wnt/beta-catenin signaling stem from alteration in phosphorylation-dependent protein degradation and subcellular localization of beta-catenin from cell membrane to the nucleus, where it binds to T-cell factor (Tcf) to form a bipartite transcription factor. The beta-catenin/Tcf complex facilitates transcription of target genes that encode effectors for activation of cell proliferation and invasion and inhibition of apoptosis, leading to colorectal cancer development. In addition, in the tumor invasion front, stabilized and activated beta-catenin interacts with other molecular pathways to facilitate tumor progression. This review highlights the beta-catenin-dependent oncogenic signaling network involved in the multi-step process of colorectal tumorigenesis. Wnt signaling evidently regulates stem cells, leading them to differentiate or self-renew. We address roles of oncogenic beta-catenin signaling in the microenvironment of the tumor-host interface that determine the individual tumor's malignant potential and in regulation of putative cancer stem or progenitor cells that represent plausible targets for cancer eradication.

Original languageEnglish (US)
Pages (from-to)1522-1539
Number of pages18
JournalCell cycle (Georgetown, Tex.)
Volume4
Issue number11
DOIs
StatePublished - Jan 1 2005

Fingerprint

beta Catenin
Colorectal Neoplasms
TCF Transcription Factors
Neoplasms
Stem Cells
Tumor Microenvironment
Neoplastic Stem Cells
Cell Adhesion
Proteolysis
Embryonic Development
Signal Transduction
Carcinogenesis
Transcription Factors
Phosphorylation
Cell Proliferation
Cell Membrane
Apoptosis
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Fuchs, Serge Y. ; Ougolkov, Andrei V. ; Spiegelman, Vladimir ; Minamoto, Toshinari. / Oncogenic beta-catenin signaling networks in colorectal cancer. In: Cell cycle (Georgetown, Tex.). 2005 ; Vol. 4, No. 11. pp. 1522-1539.
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Oncogenic beta-catenin signaling networks in colorectal cancer. / Fuchs, Serge Y.; Ougolkov, Andrei V.; Spiegelman, Vladimir; Minamoto, Toshinari.

In: Cell cycle (Georgetown, Tex.), Vol. 4, No. 11, 01.01.2005, p. 1522-1539.

Research output: Contribution to journalReview article

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