One-pot synthesis of (±)-1′a-carba-1′aβ-hydroxycytidine - a new carbocyclic analogue of cytidine

Dhimant Desai, Azzouz Ben Cheikh, Jiri Zemlicka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The title compound 1 was synthesized by a one-pot (two-step) procedure starting from aminocyclopentane tetrol 2 and BrCN at pH 9 followed by reaction with cyanoacetylene in 1 M NH4OH. Oxazolines 3 and 4 are intermediates in the synthesis.

Original languageEnglish (US)
Pages (from-to)6281-6284
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number44
DOIs
StatePublished - Oct 28 1991

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Cytidine
cyanoacetylene
carbodine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

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title = "One-pot synthesis of (±)-1′a-carba-1′aβ-hydroxycytidine - a new carbocyclic analogue of cytidine",
abstract = "The title compound 1 was synthesized by a one-pot (two-step) procedure starting from aminocyclopentane tetrol 2 and BrCN at pH 9 followed by reaction with cyanoacetylene in 1 M NH4OH. Oxazolines 3 and 4 are intermediates in the synthesis.",
author = "Dhimant Desai and Cheikh, {Azzouz Ben} and Jiri Zemlicka",
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One-pot synthesis of (±)-1′a-carba-1′aβ-hydroxycytidine - a new carbocyclic analogue of cytidine. / Desai, Dhimant; Cheikh, Azzouz Ben; Zemlicka, Jiri.

In: Tetrahedron Letters, Vol. 32, No. 44, 28.10.1991, p. 6281-6284.

Research output: Contribution to journalArticle

TY - JOUR

T1 - One-pot synthesis of (±)-1′a-carba-1′aβ-hydroxycytidine - a new carbocyclic analogue of cytidine

AU - Desai, Dhimant

AU - Cheikh, Azzouz Ben

AU - Zemlicka, Jiri

PY - 1991/10/28

Y1 - 1991/10/28

N2 - The title compound 1 was synthesized by a one-pot (two-step) procedure starting from aminocyclopentane tetrol 2 and BrCN at pH 9 followed by reaction with cyanoacetylene in 1 M NH4OH. Oxazolines 3 and 4 are intermediates in the synthesis.

AB - The title compound 1 was synthesized by a one-pot (two-step) procedure starting from aminocyclopentane tetrol 2 and BrCN at pH 9 followed by reaction with cyanoacetylene in 1 M NH4OH. Oxazolines 3 and 4 are intermediates in the synthesis.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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