One-pot synthesis of (±)-1′a-carba-1′aβ-hydroxycytidine - a new carbocyclic analogue of cytidine

Dhimant H. Desai, Azzouz Ben Cheikh, Jiri Zemlicka

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Abstract

The title compound 1 was synthesized by a one-pot (two-step) procedure starting from aminocyclopentane tetrol 2 and BrCN at pH 9 followed by reaction with cyanoacetylene in 1 M NH4OH. Oxazolines 3 and 4 are intermediates in the synthesis.

Original languageEnglish (US)
Pages (from-to)6281-6284
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number44
DOIs
StatePublished - Oct 28 1991

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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