Online resources for genomic analysis using high-throughput sequencing

Daniel James Blankenberg, James Taylor, Anton Nekrutenko

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The availability of high-throughput sequencing has created enormous possibilities for scientific discovery. However, the massive amount of data being generated has resulted in a severe informatics bottleneck. A large number of tools exist for analyzing next-generation sequencing (NGS) data, yet often there remains a disconnect between these research tools and the ability of many researchers to use them. As a consequence, several online resources and communities have been developed to assist researchers with both the management and the analysis of sequencing data sets. Here we describe the use and applications of common file formats for coding and storing genomic data, consider several web-accessible open-source resources for the visualization and analysis of NGS data, and provide examples of typical analyses with links to further detailed exercises.

Original languageEnglish (US)
Pages (from-to)324-335
Number of pages12
JournalCold Spring Harbor Protocols
Volume2015
Issue number4
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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