Opioid antagonists inhibit the growth of metastatic murine neuroblastoma

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20Y neuroblastoma (NB) in A Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in 100% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalCancer Letters
Volume21
Issue number1
DOIs
StatePublished - Nov 1983

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Naltrexone
Narcotic Antagonists
Neuroblastoma
Growth
Opiate Alkaloids
Neoplasms
Antineoplastic Agents
Opioid Analgesics
Neoplasm Metastasis
Injections
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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abstract = "Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20Y neuroblastoma (NB) in A Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69{\%} tumor take, 70{\%} delay in time prior to tumor appearance, and a 60{\%} increase in median survival time. Inoculation of NB in control mice resulted in 100{\%} tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.",
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Opioid antagonists inhibit the growth of metastatic murine neuroblastoma. / Zagon, Ian S.; McLaughlin, Patricia J.

In: Cancer Letters, Vol. 21, No. 1, 11.1983, p. 89-94.

Research output: Contribution to journalArticle

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