Optimization of a compliant endoscopic radiofrequency ablation electrode

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Radiofrequency ablation (RFA) is a common cancer treatment modality for patients who are ineligible for open surgery. There is a need for RFA electrodes that generate heating zones that closely match the geometry of typical tumors, especially for endoscopic ultrasound-guided (EUS) RFA. In this paper, the procedure for optimization of an RFA electrode is presented. First, a novel compliant electrode design is proposed. Next, a thermal ablation model is developed to predict the ablation zone surrounding an RFA electrode in biological tissue. Then, a multi-objective genetic algorithm is used to optimize two cases of the electrode geometry to match the region of destructed tissue to a spherical tumor of specified diameter. This optimization procedure is applied to an EUS-RFA ablation of pancreatic tissue. For a target 2.5cm spherical tumor, the optimal design parameters of the compliant electrode design were found. After simulating 40 generations of 50 designs per generation, both cases converged to optimal solutions. The objective functions were useful for simple electrode designs. For more complex electrode designs, the objective functions were unable to direct the design toward a 2.5cm sphere. The results of the optimization demonstrate how computational models combined with optimization can be used for systematic design of ablation electrodes. The optimization procedure may be applied to RFA of various tissue types for systematic design of electrodes that generate spherical ablation zones.

Original languageEnglish (US)
Title of host publication41st Mechanisms and Robotics Conference
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791858172
DOIs
StatePublished - Jan 1 2017
EventASME 2017 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2017 - Cleveland, United States
Duration: Aug 6 2017Aug 9 2017

Publication series

NameProceedings of the ASME Design Engineering Technical Conference
Volume5A-2017

Other

OtherASME 2017 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2017
CountryUnited States
CityCleveland
Period8/6/178/9/17

Fingerprint

Ablation
Electrode
Electrodes
Optimization
Tissue
Tumors
Tumor
Ultrasound
Objective function
Ultrasonics
Biological Tissue
Oncology
Multi-objective Genetic Algorithm
Geometry
Design
Computational Model
Modality
Surgery
Heating
Cancer

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering
  • Computer Graphics and Computer-Aided Design
  • Computer Science Applications
  • Modeling and Simulation

Cite this

Hanks, B., Frecker, M. I., & Moyer, M. (2017). Optimization of a compliant endoscopic radiofrequency ablation electrode. In 41st Mechanisms and Robotics Conference (Proceedings of the ASME Design Engineering Technical Conference; Vol. 5A-2017). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/DETC2017-67357
Hanks, Bradley ; Frecker, Mary I. ; Moyer, Matthew. / Optimization of a compliant endoscopic radiofrequency ablation electrode. 41st Mechanisms and Robotics Conference. American Society of Mechanical Engineers (ASME), 2017. (Proceedings of the ASME Design Engineering Technical Conference).
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Hanks, B, Frecker, MI & Moyer, M 2017, Optimization of a compliant endoscopic radiofrequency ablation electrode. in 41st Mechanisms and Robotics Conference. Proceedings of the ASME Design Engineering Technical Conference, vol. 5A-2017, American Society of Mechanical Engineers (ASME), ASME 2017 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2017, Cleveland, United States, 8/6/17. https://doi.org/10.1115/DETC2017-67357

Optimization of a compliant endoscopic radiofrequency ablation electrode. / Hanks, Bradley; Frecker, Mary I.; Moyer, Matthew.

41st Mechanisms and Robotics Conference. American Society of Mechanical Engineers (ASME), 2017. (Proceedings of the ASME Design Engineering Technical Conference; Vol. 5A-2017).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Hanks B, Frecker MI, Moyer M. Optimization of a compliant endoscopic radiofrequency ablation electrode. In 41st Mechanisms and Robotics Conference. American Society of Mechanical Engineers (ASME). 2017. (Proceedings of the ASME Design Engineering Technical Conference). https://doi.org/10.1115/DETC2017-67357