Optimization of image registration and application to human disc mechanics with nucleotomy

K. M. Gerasimowicz; J. H. Yoder; N. J. Tustison; G. Song; G. D. O'Connell; N. R. Malhotra; E. J. Vresilovic; A. C. Wright; J. C. Gee; D. M. Elliott

doi:10.1109/NEBC.2011.5778690

Optimization of image registration and application to human disc mechanics with nucleotomy

K. M. Gerasimowicz, J. H. Yoder, N. J. Tustison, G. Song, G. D. O'Connell, N. R. Malhotra, E. J. Vresilovic, A. C. Wright, J. C. Gee, D. M. Elliott

Department of Orthopaedics and Rehabilitation

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Introduction: Advanced Normalization Tools (ANTs) is an image registration program that has been validated for analysis of several tissues, but not previously applied to the disc. The objectives of this study were to optimize ANTs for disc image registration and to validate ANTs strain measurements by comparison with Vic2D, a commercially available software previously applied to quantify disc strain, before and after nucleotomy. Methods: Human lumbar motion segments (n=5) underwent 1000 N compression before and after nucleotomy and MR images were acquired in a reference and deformed state. Image overlap statistics were used to select mapping parameters, and strain analysis was used to select the optimal number of splines. Once the optimal registration method was selected (elastic mapping, 0.01 outlier, 6x6 splines), axial and radial strains were measured in the AAF, PAF, and IVD. Results: Excellent overlap statistics were achieved. No significant differences were found for strains calculated with ANTs and Vic2D (p≥0.35). With nucleotomy, the axial compressive strain increased in the PAF (p=0.04) and there was a trend towards decrease in radial strain (p=0.07). Discussion: ANTs is an accurate and powerful tool to calculate disc strains from MR images.

Original language	English (US)
Title of host publication	2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
DOIs	https://doi.org/10.1109/NEBC.2011.5778690
State	Published - Jun 16 2011
Event	37th Annual Northeast Bioengineering Conference, NEBEC 2011 - Troy, NY, United States Duration: Apr 1 2011 → Apr 3 2011

Publication series

Name	2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011

Other

Other	37th Annual Northeast Bioengineering Conference, NEBEC 2011
Country/Territory	United States
City	Troy, NY
Period	4/1/11 → 4/3/11

All Science Journal Classification (ASJC) codes

Bioengineering

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10.1109/NEBC.2011.5778690

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Gerasimowicz, K. M., Yoder, J. H., Tustison, N. J., Song, G., O'Connell, G. D., Malhotra, N. R., Vresilovic, E. J., Wright, A. C., Gee, J. C., & Elliott, D. M. (2011). Optimization of image registration and application to human disc mechanics with nucleotomy. In 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011 [5778690] (2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011). https://doi.org/10.1109/NEBC.2011.5778690

@inproceedings{fc69872be1664d278c46098336c37f99,

title = "Optimization of image registration and application to human disc mechanics with nucleotomy",

abstract = "Introduction: Advanced Normalization Tools (ANTs) is an image registration program that has been validated for analysis of several tissues, but not previously applied to the disc. The objectives of this study were to optimize ANTs for disc image registration and to validate ANTs strain measurements by comparison with Vic2D, a commercially available software previously applied to quantify disc strain, before and after nucleotomy. Methods: Human lumbar motion segments (n=5) underwent 1000 N compression before and after nucleotomy and MR images were acquired in a reference and deformed state. Image overlap statistics were used to select mapping parameters, and strain analysis was used to select the optimal number of splines. Once the optimal registration method was selected (elastic mapping, 0.01 outlier, 6x6 splines), axial and radial strains were measured in the AAF, PAF, and IVD. Results: Excellent overlap statistics were achieved. No significant differences were found for strains calculated with ANTs and Vic2D (p≥0.35). With nucleotomy, the axial compressive strain increased in the PAF (p=0.04) and there was a trend towards decrease in radial strain (p=0.07). Discussion: ANTs is an accurate and powerful tool to calculate disc strains from MR images.",

author = "Gerasimowicz, {K. M.} and Yoder, {J. H.} and Tustison, {N. J.} and G. Song and O'Connell, {G. D.} and Malhotra, {N. R.} and Vresilovic, {E. J.} and Wright, {A. C.} and Gee, {J. C.} and Elliott, {D. M.}",

year = "2011",

month = jun,

day = "16",

doi = "10.1109/NEBC.2011.5778690",

language = "English (US)",

isbn = "9781612848273",

series = "2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011",

booktitle = "2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011",

note = "37th Annual Northeast Bioengineering Conference, NEBEC 2011 ; Conference date: 01-04-2011 Through 03-04-2011",

}

Gerasimowicz, KM, Yoder, JH, Tustison, NJ, Song, G, O'Connell, GD, Malhotra, NR, Vresilovic, EJ, Wright, AC, Gee, JC & Elliott, DM 2011, Optimization of image registration and application to human disc mechanics with nucleotomy. in 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011., 5778690, 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011, 37th Annual Northeast Bioengineering Conference, NEBEC 2011, Troy, NY, United States, 4/1/11. https://doi.org/10.1109/NEBC.2011.5778690

Optimization of image registration and application to human disc mechanics with nucleotomy. / Gerasimowicz, K. M.; Yoder, J. H.; Tustison, N. J. et al.
2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011. 2011. 5778690 (2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Optimization of image registration and application to human disc mechanics with nucleotomy

AU - Gerasimowicz, K. M.

AU - Yoder, J. H.

AU - Tustison, N. J.

AU - Song, G.

AU - O'Connell, G. D.

AU - Malhotra, N. R.

AU - Vresilovic, E. J.

AU - Wright, A. C.

AU - Gee, J. C.

AU - Elliott, D. M.

PY - 2011/6/16

Y1 - 2011/6/16

N2 - Introduction: Advanced Normalization Tools (ANTs) is an image registration program that has been validated for analysis of several tissues, but not previously applied to the disc. The objectives of this study were to optimize ANTs for disc image registration and to validate ANTs strain measurements by comparison with Vic2D, a commercially available software previously applied to quantify disc strain, before and after nucleotomy. Methods: Human lumbar motion segments (n=5) underwent 1000 N compression before and after nucleotomy and MR images were acquired in a reference and deformed state. Image overlap statistics were used to select mapping parameters, and strain analysis was used to select the optimal number of splines. Once the optimal registration method was selected (elastic mapping, 0.01 outlier, 6x6 splines), axial and radial strains were measured in the AAF, PAF, and IVD. Results: Excellent overlap statistics were achieved. No significant differences were found for strains calculated with ANTs and Vic2D (p≥0.35). With nucleotomy, the axial compressive strain increased in the PAF (p=0.04) and there was a trend towards decrease in radial strain (p=0.07). Discussion: ANTs is an accurate and powerful tool to calculate disc strains from MR images.

AB - Introduction: Advanced Normalization Tools (ANTs) is an image registration program that has been validated for analysis of several tissues, but not previously applied to the disc. The objectives of this study were to optimize ANTs for disc image registration and to validate ANTs strain measurements by comparison with Vic2D, a commercially available software previously applied to quantify disc strain, before and after nucleotomy. Methods: Human lumbar motion segments (n=5) underwent 1000 N compression before and after nucleotomy and MR images were acquired in a reference and deformed state. Image overlap statistics were used to select mapping parameters, and strain analysis was used to select the optimal number of splines. Once the optimal registration method was selected (elastic mapping, 0.01 outlier, 6x6 splines), axial and radial strains were measured in the AAF, PAF, and IVD. Results: Excellent overlap statistics were achieved. No significant differences were found for strains calculated with ANTs and Vic2D (p≥0.35). With nucleotomy, the axial compressive strain increased in the PAF (p=0.04) and there was a trend towards decrease in radial strain (p=0.07). Discussion: ANTs is an accurate and powerful tool to calculate disc strains from MR images.

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Optimization of image registration and application to human disc mechanics with nucleotomy

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