Optimization of remotely delivered intensive lifestyle treatment for obesity using the Multiphase Optimization Strategy: Opt-IN study protocol

Christine A. Pellegrini, Sara A. Hoffman, Linda Marie Collins, Bonnie Spring

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Obesity-attributable medical expenditures remain high, and interventions that are both effective and cost-effective have not been adequately developed. The Opt-IN study is a theory-guided trial using the Multiphase Optimization Strategy (MOST) to develop an optimized, scalable version of a technology-supported weight loss intervention. Objective: Opt-IN aims to identify which of 5 treatment components or component levels contribute most meaningfully and cost-efficiently to the improvement of weight loss over a 6. month period. Study design: Five hundred and sixty obese adults (BMI 30-40kg/m2) between 18 and 60years old will be randomized to one of 16 conditions in a fractional factorial design involving five intervention components: treatment intensity (12 vs. 24 coaching calls), reports sent to primary care physician (No vs. Yes), text messaging (No vs. Yes), meal replacement recommendations (No vs. Yes), and training of a participant's self-selected support buddy (No vs. Yes). During the 6-month intervention, participants will monitor weight, diet, and physical activity on the Opt-IN smartphone application downloaded to their personal phone. Weight will be assessed at baseline, 3, and 6months. Significance: The Opt-IN trial is the first study to use the MOST framework to develop a weight loss treatment that will be optimized to yield the best weight loss outcome attainable for $500 or less.

Original languageEnglish (US)
Pages (from-to)251-259
Number of pages9
JournalContemporary Clinical Trials
Volume38
Issue number2
DOIs
StatePublished - Jan 1 2014

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Life Style
Weight Loss
Obesity
Text Messaging
Weights and Measures
Costs and Cost Analysis
Primary Care Physicians
Therapeutics
Health Expenditures
Meals
Exercise
Diet
Technology

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

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abstract = "Background: Obesity-attributable medical expenditures remain high, and interventions that are both effective and cost-effective have not been adequately developed. The Opt-IN study is a theory-guided trial using the Multiphase Optimization Strategy (MOST) to develop an optimized, scalable version of a technology-supported weight loss intervention. Objective: Opt-IN aims to identify which of 5 treatment components or component levels contribute most meaningfully and cost-efficiently to the improvement of weight loss over a 6. month period. Study design: Five hundred and sixty obese adults (BMI 30-40kg/m2) between 18 and 60years old will be randomized to one of 16 conditions in a fractional factorial design involving five intervention components: treatment intensity (12 vs. 24 coaching calls), reports sent to primary care physician (No vs. Yes), text messaging (No vs. Yes), meal replacement recommendations (No vs. Yes), and training of a participant's self-selected support buddy (No vs. Yes). During the 6-month intervention, participants will monitor weight, diet, and physical activity on the Opt-IN smartphone application downloaded to their personal phone. Weight will be assessed at baseline, 3, and 6months. Significance: The Opt-IN trial is the first study to use the MOST framework to develop a weight loss treatment that will be optimized to yield the best weight loss outcome attainable for $500 or less.",
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Optimization of remotely delivered intensive lifestyle treatment for obesity using the Multiphase Optimization Strategy : Opt-IN study protocol. / Pellegrini, Christine A.; Hoffman, Sara A.; Collins, Linda Marie; Spring, Bonnie.

In: Contemporary Clinical Trials, Vol. 38, No. 2, 01.01.2014, p. 251-259.

Research output: Contribution to journalArticle

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