Optimizing bisphosphonate therapy in patients with breast cancer on endocrine therapy.

Research output: Contribution to journalReview article

Abstract

Deterioration of bone health is a major concern during progression and treatment of patients with breast cancer, especially in postmenopausal women. Disease- and treatment-associated skeletal-related events include fractures, spinal compression, bone pain, and hypercalcemia of malignancy. Bisphosphonates, which inhibit osteoclastic bone resorption, are important new agents in the management of skeletal-related events, and their impact on breast cancer-related bone metastases and on bone loss during long-term estrogen deprivation therapies such as aromatase inhibitors is reviewed. Intravenous pamidronate has become the standard bisphosphonate to reduce or delay skeletal complications of advanced breast cancer bone metastases, but the more potent agent, zoledronic acid, appears to be at least as effective. Another agent, ibandronate, is also active but has not been investigated in comparison with the other intravenous bisphosphonates. Zoledronic acid is the most convenient to administer, requiring only a short infusion. The effects of bisphosphonates on bone health in women with early breast cancer are also being investigated. A single yearly infusion of zoledronic acid has been shown to significantly increase bone mineral density in osteoporotic postmenopausal women and to reduce biochemical markers of bone turnover. The possibility of such treatment-reversing aromatase inhibitor-associated bone loss during adjuvant therapy of breast cancer is being evaluated in a trial of letrozole, with zoledronic acid added initially or after the onset of bone loss or fracture.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalSeminars in Oncology
Volume31
Issue number6 Suppl 12
StatePublished - Dec 1 2004

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zoledronic acid
Diphosphonates
Breast Neoplasms
Bone and Bones
Bone Neoplasms
Aromatase Inhibitors
pamidronate
letrozole
Therapeutics
Spinal Fractures
Neoplasm Metastasis
Compression Fractures
Bone Remodeling
Hypercalcemia
Women's Health
Bone Resorption
Bone Density
Estrogens
Biomarkers
Pain

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

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title = "Optimizing bisphosphonate therapy in patients with breast cancer on endocrine therapy.",
abstract = "Deterioration of bone health is a major concern during progression and treatment of patients with breast cancer, especially in postmenopausal women. Disease- and treatment-associated skeletal-related events include fractures, spinal compression, bone pain, and hypercalcemia of malignancy. Bisphosphonates, which inhibit osteoclastic bone resorption, are important new agents in the management of skeletal-related events, and their impact on breast cancer-related bone metastases and on bone loss during long-term estrogen deprivation therapies such as aromatase inhibitors is reviewed. Intravenous pamidronate has become the standard bisphosphonate to reduce or delay skeletal complications of advanced breast cancer bone metastases, but the more potent agent, zoledronic acid, appears to be at least as effective. Another agent, ibandronate, is also active but has not been investigated in comparison with the other intravenous bisphosphonates. Zoledronic acid is the most convenient to administer, requiring only a short infusion. The effects of bisphosphonates on bone health in women with early breast cancer are also being investigated. A single yearly infusion of zoledronic acid has been shown to significantly increase bone mineral density in osteoporotic postmenopausal women and to reduce biochemical markers of bone turnover. The possibility of such treatment-reversing aromatase inhibitor-associated bone loss during adjuvant therapy of breast cancer is being evaluated in a trial of letrozole, with zoledronic acid added initially or after the onset of bone loss or fracture.",
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Optimizing bisphosphonate therapy in patients with breast cancer on endocrine therapy. / Harvey, Harold A.

In: Seminars in Oncology, Vol. 31, No. 6 Suppl 12, 01.12.2004, p. 23-30.

Research output: Contribution to journalReview article

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