Optimizing Telemedicine to Facilitate ALS Clinical Trials

Raghav Govindarajan, James D. Berr, Sabrina Paganon, Michael T. Pulley, Zachary Simmons

Research output: Contribution to journalComment/debate

Abstract

ALS has the largest drug pipeline among neuromuscular diseases, with over 160 companies actively involved in ALS research. There is a growing need to recruit trial participants, but ALS patients often have limited mobility and most ALS trials are conducted in a small number of major centers. These factors effectively limit patient participation, particularly for those in rural areas. The current COVID-19 pandemic has necessitated the more widespread use of telemedicine technology for clinical care, and has prompted consideration of its increased use for clinical trials. In this opinion piece, we describe the current state of telemedicine for recruitment, consenting and screening of participants for clinical trials. We also summarize the available data on remote administration of outcome measures. Current challenges include validation of outcome measures for remote assessment, as well as technological, regulatory and licensure barriers. This article is protected by copyright. All rights reserved.

Original languageEnglish (US)
JournalMuscle and Nerve
DOIs
StateAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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  • Cite this

    Govindarajan, R., Berr, J. D., Paganon, S., Pulley, M. T., & Simmons, Z. (Accepted/In press). Optimizing Telemedicine to Facilitate ALS Clinical Trials. Muscle and Nerve. https://doi.org/10.1002/mus.26921