TY - JOUR
T1 - ORAI channels in cellular remodeling of cardiorespiratory disease
AU - Johnson, Martin
AU - Trebak, Mohamed
N1 - Funding Information:
Research in the authors’ laboratories is supported by grants R01HL123364 , R01HL097111 and R21AG050072 from the National Institutes of Health and by grant NPRP8-110-3-021 from the Qatar National Research Fund (QNRF) to M.T. and by a training grant TL1TR002016 from the National Center for Advancing Translational Sciences of the National Institute of Health to M.J.
Publisher Copyright:
© 2019
PY - 2019/5
Y1 - 2019/5
N2 - Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca 2+ ) signaling and specifically ORAI Ca 2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.
AB - Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca 2+ ) signaling and specifically ORAI Ca 2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.
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U2 - 10.1016/j.ceca.2019.01.005
DO - 10.1016/j.ceca.2019.01.005
M3 - Review article
C2 - 30772685
AN - SCOPUS:85061434037
SN - 0143-4160
VL - 79
SP - 1
EP - 10
JO - Cell Calcium
JF - Cell Calcium
ER -