ORAI channels in cellular remodeling of cardiorespiratory disease

Martin Johnson, Mohamed Trebak

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca 2+ ) signaling and specifically ORAI Ca 2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalCell Calcium
Volume79
DOIs
StatePublished - May 2019

Fingerprint

Ion Channels
Pulmonary Hypertension
Chronic Obstructive Pulmonary Disease
Smooth Muscle
Atherosclerosis
Blood Platelets
Asthma
Hypertension
Calcium
Growth
Therapeutics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

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title = "ORAI channels in cellular remodeling of cardiorespiratory disease",
abstract = "Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca 2+ ) signaling and specifically ORAI Ca 2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.",
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ORAI channels in cellular remodeling of cardiorespiratory disease. / Johnson, Martin; Trebak, Mohamed.

In: Cell Calcium, Vol. 79, 05.2019, p. 1-10.

Research output: Contribution to journalReview article

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T1 - ORAI channels in cellular remodeling of cardiorespiratory disease

AU - Johnson, Martin

AU - Trebak, Mohamed

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AB - Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca 2+ ) signaling and specifically ORAI Ca 2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.

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