Oral contraceptive use is associated with increased cardiovascular reactivity in nonsmokers

Sheila G. West, Catherine M. Stoney, Joel W. Hughes, Mala Matacin, Karen M. Emmons

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Women who smoke and take oral contraceptives (OCs) have significantly increased risk of cardiovascular disease, but the exact mechanisms for the increased risk are not known. Cardiovascular reactivity to psychological stress may be one mechanism for the enhanced risk, but the small number of studies examining whether OC users who smoke have greater reactivity have produced mixed results. The purpose of this study was to examine the effect of chronic cigarette smoking, acute nicotine administration, and OC use on cardiovascular and lipid reactivity. Sixty healthy women, half of whom had been using OCs for at least the previous 6 months, participated in the study. Approximately two thirds were smokers and were randomized to be tested after either a 12-hr nicotine deprivation or administration of nicotine gum. One third were nonsmokers. Heart rate, blood pressure, and lipid measures were taken at rest, during a videotaped speech task, and during recovery from the task. Results indicated that, among OC nonusers, there was no effect of smoking status or nicotine administration on cardiovascular reactivity. However, among OC users, nonsmokers had significantly greater heart rate and diastolic blood pressure reactivity to stress. These data show that acute nicotine administration, in the form of nicotine gum, has no effect on cardiovascular or lipid stress reactivity in women. However, OC use among nonsmoking women is associated with greater cardiovascular reactivity to stress.

Original languageEnglish (US)
Pages (from-to)149-157
Number of pages9
JournalAnnals of Behavioral Medicine
Volume23
Issue number3
DOIs
StatePublished - Jan 1 2001

Fingerprint

Oral Contraceptives
Nicotine
Blood Pressure
Lipids
Smoke
Heart Rate
Smoking
Psychological Stress
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Psychology(all)
  • Psychiatry and Mental health

Cite this

West, Sheila G. ; Stoney, Catherine M. ; Hughes, Joel W. ; Matacin, Mala ; Emmons, Karen M. / Oral contraceptive use is associated with increased cardiovascular reactivity in nonsmokers. In: Annals of Behavioral Medicine. 2001 ; Vol. 23, No. 3. pp. 149-157.
@article{244000a1e3aa4f43b3f10f6e1334f424,
title = "Oral contraceptive use is associated with increased cardiovascular reactivity in nonsmokers",
abstract = "Women who smoke and take oral contraceptives (OCs) have significantly increased risk of cardiovascular disease, but the exact mechanisms for the increased risk are not known. Cardiovascular reactivity to psychological stress may be one mechanism for the enhanced risk, but the small number of studies examining whether OC users who smoke have greater reactivity have produced mixed results. The purpose of this study was to examine the effect of chronic cigarette smoking, acute nicotine administration, and OC use on cardiovascular and lipid reactivity. Sixty healthy women, half of whom had been using OCs for at least the previous 6 months, participated in the study. Approximately two thirds were smokers and were randomized to be tested after either a 12-hr nicotine deprivation or administration of nicotine gum. One third were nonsmokers. Heart rate, blood pressure, and lipid measures were taken at rest, during a videotaped speech task, and during recovery from the task. Results indicated that, among OC nonusers, there was no effect of smoking status or nicotine administration on cardiovascular reactivity. However, among OC users, nonsmokers had significantly greater heart rate and diastolic blood pressure reactivity to stress. These data show that acute nicotine administration, in the form of nicotine gum, has no effect on cardiovascular or lipid stress reactivity in women. However, OC use among nonsmoking women is associated with greater cardiovascular reactivity to stress.",
author = "West, {Sheila G.} and Stoney, {Catherine M.} and Hughes, {Joel W.} and Mala Matacin and Emmons, {Karen M.}",
year = "2001",
month = "1",
day = "1",
doi = "10.1207/S15324796ABM2303_2",
language = "English (US)",
volume = "23",
pages = "149--157",
journal = "Annals of Behavioral Medicine",
issn = "0883-6612",
publisher = "Springer New York",
number = "3",

}

Oral contraceptive use is associated with increased cardiovascular reactivity in nonsmokers. / West, Sheila G.; Stoney, Catherine M.; Hughes, Joel W.; Matacin, Mala; Emmons, Karen M.

In: Annals of Behavioral Medicine, Vol. 23, No. 3, 01.01.2001, p. 149-157.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oral contraceptive use is associated with increased cardiovascular reactivity in nonsmokers

AU - West, Sheila G.

AU - Stoney, Catherine M.

AU - Hughes, Joel W.

AU - Matacin, Mala

AU - Emmons, Karen M.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Women who smoke and take oral contraceptives (OCs) have significantly increased risk of cardiovascular disease, but the exact mechanisms for the increased risk are not known. Cardiovascular reactivity to psychological stress may be one mechanism for the enhanced risk, but the small number of studies examining whether OC users who smoke have greater reactivity have produced mixed results. The purpose of this study was to examine the effect of chronic cigarette smoking, acute nicotine administration, and OC use on cardiovascular and lipid reactivity. Sixty healthy women, half of whom had been using OCs for at least the previous 6 months, participated in the study. Approximately two thirds were smokers and were randomized to be tested after either a 12-hr nicotine deprivation or administration of nicotine gum. One third were nonsmokers. Heart rate, blood pressure, and lipid measures were taken at rest, during a videotaped speech task, and during recovery from the task. Results indicated that, among OC nonusers, there was no effect of smoking status or nicotine administration on cardiovascular reactivity. However, among OC users, nonsmokers had significantly greater heart rate and diastolic blood pressure reactivity to stress. These data show that acute nicotine administration, in the form of nicotine gum, has no effect on cardiovascular or lipid stress reactivity in women. However, OC use among nonsmoking women is associated with greater cardiovascular reactivity to stress.

AB - Women who smoke and take oral contraceptives (OCs) have significantly increased risk of cardiovascular disease, but the exact mechanisms for the increased risk are not known. Cardiovascular reactivity to psychological stress may be one mechanism for the enhanced risk, but the small number of studies examining whether OC users who smoke have greater reactivity have produced mixed results. The purpose of this study was to examine the effect of chronic cigarette smoking, acute nicotine administration, and OC use on cardiovascular and lipid reactivity. Sixty healthy women, half of whom had been using OCs for at least the previous 6 months, participated in the study. Approximately two thirds were smokers and were randomized to be tested after either a 12-hr nicotine deprivation or administration of nicotine gum. One third were nonsmokers. Heart rate, blood pressure, and lipid measures were taken at rest, during a videotaped speech task, and during recovery from the task. Results indicated that, among OC nonusers, there was no effect of smoking status or nicotine administration on cardiovascular reactivity. However, among OC users, nonsmokers had significantly greater heart rate and diastolic blood pressure reactivity to stress. These data show that acute nicotine administration, in the form of nicotine gum, has no effect on cardiovascular or lipid stress reactivity in women. However, OC use among nonsmoking women is associated with greater cardiovascular reactivity to stress.

UR - http://www.scopus.com/inward/record.url?scp=0034910416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034910416&partnerID=8YFLogxK

U2 - 10.1207/S15324796ABM2303_2

DO - 10.1207/S15324796ABM2303_2

M3 - Article

C2 - 11495215

AN - SCOPUS:0034910416

VL - 23

SP - 149

EP - 157

JO - Annals of Behavioral Medicine

JF - Annals of Behavioral Medicine

SN - 0883-6612

IS - 3

ER -