Organ procurement for pulmonary transplantation

Marco Zenati, Robert Dowling, John M. Armitage, Robert L. Kormos, J. Stephen Dummer, Robert L. Hardesty, Bartley P. Griffith

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Selection of suitable donors is critical to the success of clinical pulmonary transplantation. Requirements for lung donors, management before explantation, and methods of preservation were reviewed for the 70 heart-lung, eight double-lung, and two single-lung transplantations performed at the University of Pittsburgh since 1982. Careful observation of trends of hyperoxygenation studies, chest roentgenograms, and Gram stain and culture results of tracheal secretions, as well as findings on bronchoscopy, can help identify which lungs not only have adequate function but are acceptable for transplantation. In spite of the rigid criteria used, 76% of tracheal cultures from donors deemed acceptable grew organisms. The presence of oropharyngeal flora has been shown to correlate with the development of early intrathoradci infections in the recipient. Prophylactic broadspectrum antibiotic treatment of the donor is desirable to treat microbial contamination that could cause focal injury to the donor lung and predispose to infection in the recipient. Acceptance of less than ideal donors is ill-advised even though rejection of such donors conflicts with the current shortage of organs.

Original languageEnglish (US)
Pages (from-to)882-886
Number of pages5
JournalThe Annals of thoracic surgery
Volume48
Issue number6
DOIs
StatePublished - Jan 1 1989

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Tissue and Organ Procurement
Lung Transplantation
Lung
Donor Selection
Bronchoscopy
Infection
Thorax
Transplantation
Observation
Anti-Bacterial Agents
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Zenati, M., Dowling, R., Armitage, J. M., Kormos, R. L., Dummer, J. S., Hardesty, R. L., & Griffith, B. P. (1989). Organ procurement for pulmonary transplantation. The Annals of thoracic surgery, 48(6), 882-886. https://doi.org/10.1016/0003-4975(89)90696-6
Zenati, Marco ; Dowling, Robert ; Armitage, John M. ; Kormos, Robert L. ; Dummer, J. Stephen ; Hardesty, Robert L. ; Griffith, Bartley P. / Organ procurement for pulmonary transplantation. In: The Annals of thoracic surgery. 1989 ; Vol. 48, No. 6. pp. 882-886.
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Zenati, M, Dowling, R, Armitage, JM, Kormos, RL, Dummer, JS, Hardesty, RL & Griffith, BP 1989, 'Organ procurement for pulmonary transplantation', The Annals of thoracic surgery, vol. 48, no. 6, pp. 882-886. https://doi.org/10.1016/0003-4975(89)90696-6

Organ procurement for pulmonary transplantation. / Zenati, Marco; Dowling, Robert; Armitage, John M.; Kormos, Robert L.; Dummer, J. Stephen; Hardesty, Robert L.; Griffith, Bartley P.

In: The Annals of thoracic surgery, Vol. 48, No. 6, 01.01.1989, p. 882-886.

Research output: Contribution to journalReview article

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AU - Zenati, Marco

AU - Dowling, Robert

AU - Armitage, John M.

AU - Kormos, Robert L.

AU - Dummer, J. Stephen

AU - Hardesty, Robert L.

AU - Griffith, Bartley P.

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N2 - Selection of suitable donors is critical to the success of clinical pulmonary transplantation. Requirements for lung donors, management before explantation, and methods of preservation were reviewed for the 70 heart-lung, eight double-lung, and two single-lung transplantations performed at the University of Pittsburgh since 1982. Careful observation of trends of hyperoxygenation studies, chest roentgenograms, and Gram stain and culture results of tracheal secretions, as well as findings on bronchoscopy, can help identify which lungs not only have adequate function but are acceptable for transplantation. In spite of the rigid criteria used, 76% of tracheal cultures from donors deemed acceptable grew organisms. The presence of oropharyngeal flora has been shown to correlate with the development of early intrathoradci infections in the recipient. Prophylactic broadspectrum antibiotic treatment of the donor is desirable to treat microbial contamination that could cause focal injury to the donor lung and predispose to infection in the recipient. Acceptance of less than ideal donors is ill-advised even though rejection of such donors conflicts with the current shortage of organs.

AB - Selection of suitable donors is critical to the success of clinical pulmonary transplantation. Requirements for lung donors, management before explantation, and methods of preservation were reviewed for the 70 heart-lung, eight double-lung, and two single-lung transplantations performed at the University of Pittsburgh since 1982. Careful observation of trends of hyperoxygenation studies, chest roentgenograms, and Gram stain and culture results of tracheal secretions, as well as findings on bronchoscopy, can help identify which lungs not only have adequate function but are acceptable for transplantation. In spite of the rigid criteria used, 76% of tracheal cultures from donors deemed acceptable grew organisms. The presence of oropharyngeal flora has been shown to correlate with the development of early intrathoradci infections in the recipient. Prophylactic broadspectrum antibiotic treatment of the donor is desirable to treat microbial contamination that could cause focal injury to the donor lung and predispose to infection in the recipient. Acceptance of less than ideal donors is ill-advised even though rejection of such donors conflicts with the current shortage of organs.

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Zenati M, Dowling R, Armitage JM, Kormos RL, Dummer JS, Hardesty RL et al. Organ procurement for pulmonary transplantation. The Annals of thoracic surgery. 1989 Jan 1;48(6):882-886. https://doi.org/10.1016/0003-4975(89)90696-6