Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice

Julie Helft, Florent Ginhoux, Milena Bogunovic, Miriam Merad

Research output: Contribution to journalReview articlepeer-review

162 Scopus citations

Abstract

Dendritic cells (DCs) have been extensively studied in mice lymphoid organs, but less is known about the origin and the mechanisms that regulate DC development and function in non-lymphoid tissues. Here, we discuss recent evidence establishing the contribution of the DC-restricted lineage to the non-lymphoid tissue DC pool and discuss the mechanisms that control the homeostasis of non-lymphoid tissue DCs. We also review recent results underlining the functional specialization of tissue DCs and discuss the potential implications of these findings in tissue immunity and in the development of novel vaccine strategies.

Original languageEnglish (US)
Pages (from-to)55-75
Number of pages21
JournalImmunological Reviews
Volume234
Issue number1
DOIs
StatePublished - Mar 2010

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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